Influence of sucrose esters on the in vivo percutaneous penetration of octyl methoxycinnamate formulated in nanocapsules, nanoemulsion, and emulsion
Influence of sucrose esters on the in vivo percutaneous penetration of octyl methoxycinnamate formulated in nanocapsules, nanoemulsion, and emulsion
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DOI：
10.1080/03639040500388540
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发表时间：
2006-01-01
影响因子：
3.4
通讯作者：
Robles, R
中科院分区：
文献类型：
--
作者：
Calderilla-Fajardo, SB;Cázares-Delgadillo, J;Robles, R
评估了蔗糖月桂酸酯和蔗糖油酸酯对配制在i）胶体悬浮液（纳米乳液和纳米胶囊）和ii）传统o/w乳液中的甲氧基肉桂酸辛酯（OMC）体内经皮渗透的影响。结果表明，与其他制剂相比，用蔗糖月桂酸酯配制的纳米乳剂在角质层中表现出最高的渗透性。当与对照相比时，用含有蔗糖月桂酸酯的纳米乳液观察到OMC皮肤沉积增加两倍。所获得的数据表明，在角质层中检测到的OMC的总量和渗透深度强烈依赖于制剂的性质、粒度和增强剂的类型。
The influence of sucrose laureate and sucrose oleate on the in vivo percutaneous penetration of octyl methoxycinnamate (OMC) formulated in i) colloidal suspensions (nano-emulsions and nanocapsules), and ii) conventional o/w emulsions was evaluated. The results showed that nano-emulsions formulated with sucrose laureate exhibited the highest penetration in the stratum corneum compared to the other formulations. A two-fold increase in OMC skin deposition was observed with the nano-emulsion containing sucrose laureate when compared to the control. The data obtained suggest that the total amount of OMC detected in the stratum corneum and the penetration depth are strongly dependent upon the formulation's nature, the particle size, and the type of enhancer.