Nontypable Haemophilus influenzae: a review of clinical aspects, surface antigens, and the human immune response to infection.
Nontypable Haemophilus influenzae: a review of clinical aspects, surface antigens, and the human immune response to infection.
复制标题
不可分型流感嗜血杆菌：临床方面、表面抗原和人体对感染的免疫反应的综述。
DOI：
10.1093/clinids/9.1.1
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Apicella,MA
中科院分区：
文献类型：
--
作者：
Murphy,TF;Apicella,MA
非典型流感嗜血杆菌现已成为成人和儿童的重要病原体。最近的工作已经确定了无定型和B型H.这些生物体影响不同的患者群体，引起不同的感染，向宿主呈递不同的表面抗原，并且在遗传上不同。非典型H.成人流感是下呼吸道感染，尤其是老年人和慢性支气管炎患者。细菌是儿童急性中耳炎的常见原因。非典型H的表面。流感病毒由外膜蛋白和脂寡糖组成，这两种蛋白都表现出很大的抗原异质性，可用于分离株的血清分型。一些呼吸道分离株有菌毛，但菌毛在致病中的作用尚不清楚。抗外膜蛋白和脂寡糖的抗体存在于人血清中。人类对感染的免疫力的研究集中在鉴定保护性抗体所针对的那些抗原。
NontypableHaemophilus influenzaehas now become well established as an important pathogen in both adults and children. Recent work has identified clear distinctions between nontypable and type b strains ofH. influenzae.These organisms affect different patient populations, cause different infections, present different surface antigens to the host, and are genetically different. The commonest clinical manifestation of infection due to nontypableH. influenzaein adults is lower respiratory tract infection, particularly in the elderly and in those with chronic bronchitis. The bacterium is a frequent cause of acute otitis media in children. The surface of nontypableH. influenzaeis composed of outer-membrane proteins and lipooligosaccharide, and both of these demonstrate substantial antigenic heterogeneity, which can be used to serotype isolates. Some respiratory tract isolates are fimbriated, but the role of fimbriae in pathogenesis is unclear. Antibodies to outer-membrane proteins and lipooligosaccharide are present in human serum. Investigation of human immunity to infection is focusing on identification of those antigens to which protective antibody is directed.