REGULATION OF HEMOGLOBIN-FUNCTION IN MAMMALS
REGULATION OF HEMOGLOBIN-FUNCTION IN MAMMALS
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DOI：
10.1093/icb/20.1.199
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发表时间：
1980-01-01
期刊：
影响因子：
--
通讯作者：
BUNN, HF
中科院分区：
文献类型：
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作者：
BUNN, HF
这项对哺乳动物血红蛋白功能的调查揭示了氧亲和力的广泛范围。红细胞2，3-DPG的浓度在哺乳动物组之间变化很大。具有非常低水平的这种细胞内介质的那些动物（猫科动物和反刍动物）具有固有低氧亲和力的血红蛋白，其不能对2，3-DPG的添加作出响应。已经适应各种类型缺氧的哺乳动物倾向于具有增加的氧亲和力，主要通过降低的红细胞2，3 DPG水平介导。相比之下，实验性地经受低氧张力的哺乳动物由于红细胞2，3-DPG增加而发展出降低的氧亲和力。哺乳动物采用三种不同的机制来维持胎儿红细胞比母体红细胞更高的氧亲和力，其中许多现象可以在分子水平上得到满意的解释，但它们的适应意义尚不清楚。
This survey of hemoglobin function in mammals reveals a broad range in oxygen affinity. The concentration of red cell 2,3-DPG varies widely among groups of mammals. Those animals (feloids and ruminants) that have very low levels of this intracellular mediator have hemoglobins of intrinsically low oxygen affinity which fail to respond to the addition of 2,3-DPG. Mammals which have adapted to various types of hypoxia tend to have increased oxygen affinity, primarily mediated through reduced levels of red cell 2,3 DPG. In contrast mammals who are experimentally subjected to low oxygen tensions develop decreased oxygen affinity owing to increased red cell 2,3-DPG. Mammals employ one of three different mechanisms for the maintenance of higher oxygen affinity of fetal red cells, compared to maternal red cells.Many of these phenomena can be satisfactorily explained at the molecular level but their adaptational significance is less clear.