I(2)-catalyzed direct α-hydroxylation of β-dicarbonyl compounds with atmospheric oxygen under photoirradiation.
I(2)-catalyzed direct α-hydroxylation of β-dicarbonyl compounds with atmospheric oxygen under photoirradiation.
复制标题
DOI：
10.1021/jo401866p
复制
发表时间：
2013-10
期刊：
影响因子：
--
通讯作者：
Chun-Bao Miao;Yan-Hong Wang;M. Xing;Xin-Wei Lu;Xiao-qiang Sun;Hai-Tao Yang
中科院分区：
文献类型：
--
作者：
Chun-Bao Miao;Yan-Hong Wang;M. Xing;Xin-Wei Lu;Xiao-qiang Sun;Hai-Tao Yang
以空气为氧化剂，碘催化β-二羰基的羟基化反应制备α-羟基-β-二羰基化合物。仅用1摩尔%的I2就完成了转化。对于α-未取代的丙二酸酯，羟基化的二聚产物作为主要产物与次要产物α，α-二羟基丙二酸酯一起沿着提供。
An I2-catalyzed hydroxylation of β-dicarbonyl moieties using air as the oxidant under photoirradiation has been developed for the easy preparation of α-hydroxy-β-dicarbonyl compounds. The transformation was completed with only 1 mol % of I2. With α-unsubstituted malonates, the hydroxylated dimerization product was afforded as the predominant product along with a minor product, α,α-dihydroxyl malonate.