Enterococci and streptococci
Enterococci and streptococci
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DOI：
10.1016/s0924-8579(07)72177-5
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发表时间：
2007-05-01
影响因子：
10.8
通讯作者：
Amyes, Sebastian G. B.
中科院分区：
文献类型：
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作者：
Amyes, Sebastian G. B.
除了金黄色葡萄球菌外，其他革兰氏阳性菌已成为多重耐药菌，并导致治疗问题，特别是在住院患者中。屎肠球菌和粪肠球菌菌株获得万古霉素耐药性特别令人关注，并导致治疗失败。由这些细菌引起的一些感染确实对过去几年发布的新抗生素治疗有反应，但是需要更多的选择，因为并非所有肠球菌都是天生敏感的，并且在那些敏感的肠球菌中开始出现耐药性。链球菌属也出现了对常用抗生素的耐药性，特别是四环素类和大环内酯类。在这两个属中，多重耐药菌株在患者之间和医院之间传播。在实验室中，这些细菌对替加环素表现出相当大的敏感性，几乎没有产生耐药性的倾向，这表明替加环素在控制这些革兰氏阳性菌引起的感染中可以发挥重要作用。(c)2007年Elsevier B.V.和国际化疗学会。All rights reserved.
Besides Staphylococcus aureus, other Gram-positive bacteria have become multidrug-resistant and cause therapeutic problems, particularly amongst hospitalised patients. The acquisition of vancomycin resistance by strains of Enterococcus faecium and Enterococcus faecalis is of particular concern and has resulted in treatment failures. Some of the infections caused by these bacteria do respond to treatment with new antibiotics that have been released in the last few years, however more options are required as not all enterococci are inherently susceptible and resistance is beginning to emerge amongst those that were susceptible. Resistance to commonly used antibiotics is also emerging in Streptococcus spp., particularly to the tetracyclines and macrolides. In both genera, multiresistant strains spread between patients and between hospitals. In the laboratory, these bacteria show considerable susceptibility to tigecycline, with little propensity to develop resistance, indicating that tigecycline could assume an important role in controlling infections caused by these Gram-positive bacteria. (c) 2007 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.