Persistent sodium currents in mesencephalic V neurons participate in burst generation and control of membrane excitability
Persistent sodium currents in mesencephalic V neurons participate in burst generation and control of membrane excitability
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DOI：
10.1152/jn.00636.2004
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发表时间：
2005-05-01
影响因子：
2.5
通讯作者：
Chandler, SH
中科院分区：
文献类型：
--
作者：
Wu, NP;Enomoto, A;Chandler, SH
采用全细胞膜片钳技术，在大鼠脑干脑片上研究了持续性钠电流（I-NaP）的功能和生物物理特性，该电流参与中脑三叉神经感觉神经元（Mes V）阈下振荡和爆发放电的产生。I-NaP在-76 mV左右激活，峰值为-48 mV，V-1/2为-58.7 mV。斜坡电压钳方案表明，I-NaP经历时间依赖性以及电压依赖性失活和从失活恢复在几秒的范围内（tau（开始）= 2.04 s，tau（恢复）= 2.21 s）。阿托唑（
The functional and biophysical properties of a persistent sodium current (I-NaP) previously proposed to participate in the generation of subthreshold oscillations and burst discharge in mesencephalic trigeminal sensory neurons (Mes V) were investigated in brain stem slices ( rats, p7 - p12) using whole cell patch-clamp methods. I-NaP activated around - 76 mV and peaked at - 48 mV, with V-1/2 of -58.7 mV. Ramp voltage-clamp protocols showed that I-NaP undergoes time- as well as voltage-dependent inactivation and recovery from inactivation in the range of several seconds (tau(onset) = 2.04 s, tau(recov) = 2.21 s). Riluzole (