Photocrosslinked methacrylated carboxymethyl chitin hydrogels with tunable degradation and mechanical behavior
Photocrosslinked methacrylated carboxymethyl chitin hydrogels with tunable degradation and mechanical behavior
复制标题
具有可调节降解和机械行为的光交联甲基丙烯酸酯化羧甲基甲壳素水凝胶
DOI：
10.1016/j.carbpol.2016.12.032
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发表时间：
2017-03-15
影响因子：
11.2
通讯作者：
Jiang, Xulin
中科院分区：
文献类型：
--
作者：
Kang, Wenting;Bi, Bo;Jiang, Xulin
光交联的水凝胶被研究用于许多组织工程应用，因为能够通过在生理条件下注射水溶液以微创方式原位形成这些材料。本工作以均相合成的羧甲基甲壳素为原料，采用甲基丙烯酸酐对羧甲基甲壳素进行改性，制备了降解性能和力学性能可调的水凝胶。这种新的甲基丙烯酸酯化羧甲基甲壳素（Me-CMCH）水凝胶形成在紫外光照射下原位光交联显示出更高的储能模量比热敏原位形成物理交联CMCH水凝胶。该凝胶在生理条件下保持稳定，并能被溶菌酶降解。细胞毒性试验表明，光诱导的Me-CMCH水凝胶无细胞毒性。通过控制Me-CMCH的甲基丙烯酸化程度，可以调控Me-CMCH水凝胶的力学性能、形态、溶胀和生物降解性能。这些可生物降解的可光交联的Me-CMCH水凝胶可用于各种生物医学应用。(C)2016爱思唯尔有限公司版权所有
Photocrosslinked hydrogels are being investigated for many tissue engineering applications because of the ability to form these materials in-situ in a minimally invasive manner by injection of aqueous solution under physiological conditions. In this work, carboxymethyl chitin (CMCH) synthesized homogenously was further modified with methacrylic anhydride and photocrosslinked into hydrogel with tunable degradation and mechanical properties. This new methacrylated carboxymethyl chitin (Me-CMCH) hydrogel formed in-situ photocrosslinked under UV irradiation showed much higher storage modulus than that of the thermosensitive in-situ forming physical-crosslinking CMCH hydrogel. The Me-CMCH hydrogels remained stable under physiological conditions and could be degraded by lysozyme. Cytotoxicity test indicated that the photo-induced Me-CMCH hydrogels were non-cytotoxic. The mechanical property, morphology, swelling and biodegradation behavior of the Me-CMCH hydrogels could be tuned by controlling the degree of methacrylation of Me-CMCH. These biodegradable photocrosslinkable Me-CMCH hydrogels may hold great promises for various biomedical applications. (C) 2016 Elsevier Ltd. All rights reserved.