Significant elevation of plasma cathepsin B and cystatin C in patients with community-acquired pneumonia
Significant elevation of plasma cathepsin B and cystatin C in patients with community-acquired pneumonia
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DOI：
10.1016/j.cca.2011.12.010
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发表时间：
2012-03-22
影响因子：
5
通讯作者：
Yang, Shun-Fa
中科院分区：
文献类型：
--
作者：
Lee, Yuan-Ti;Chen, Shiuan-Chih;Yang, Shun-Fa
背景：我们确定了住院成人社区获得性肺炎（CAP）患者抗生素治疗前后血浆组织蛋白酶 B 和胱抑素 C 水平变化之间的关系。方法：我们收集了 61 名成人社区获得性肺炎患者抗生素治疗前后和 60 名健康对照的血液标本，并使用酶联免疫吸附测定（ELISA）测量了血浆组织蛋白酶 B 和胱抑素 C 表达浓度。确定 APACHE II、CURB-65 和肺炎严重指数 (PSI) 评分，以评估患者初次住院时的 CAP 严重程度。 结果：结果显示，抗生素治疗后，白细胞和中性粒细胞数量下降，CRP、组织蛋白酶 B、胱抑素 C 浓度和组织蛋白酶 B/胱抑素 C 比值下降。组织蛋白酶 B 的血浆浓度与 CAP 的严重程度相关，分别为 PSI 评分（r = 0.290，p = 0.025）和 CURB-65 评分（r = 0.258，p = 0.047）。半胱氨酸蛋白酶抑制剂 C 的血浆浓度与 APACHE 11 评分相关（r = 0.523，p
Background: We identified the relationship between plasma level changes of cathepsin B and cystatin C before and after antibiotic treatment in hospitalized adult patients with community-acquired pneumonia (CAP).Methods: We collected blood specimens from 61 adult patients with CAP before and after antibiotic treatment and from 60 healthy controls and measured the plasma concentrations of cathepsin B and cystatin C expression using the enzyme-linked immunosorbent assay (ELISA). The APACHE II, CURB-65, and Pneumonia Severity Index (PSI) scores were determined to assess CAP severity in patients upon initial hospitalization.Results: The results showed a decline in the number of WBCs and neutrophils, with decreases in the concentrations of CRP, cathepsin B, cystatin C, and the cathepsin B/cystatin C ratio being observed after antibiotic treatment. The plasma concentration of cathepsin B correlated with severity of CAP with the PSI score (r = 0.290, p = 0.025) and the CURB-65 score (r = 0.258, p = 0.047), respectively. The plasma concentration of cystatin C correlated with the APACHE 11 score (r = 0.523, p