Age- and species-specific duration of infection in asymptomatic malaria infections in Papua New Guinea
Age- and species-specific duration of infection in asymptomatic malaria infections in Papua New Guinea
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DOI：
10.1017/s0031182099006344
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发表时间：
2000-09-01
期刊：
影响因子：
2.4
通讯作者：
Day, KP
中科院分区：
文献类型：
--
作者：
Bruce, MC;Donnelly, CA;Day, KP
对巴布亚新几内亚马当省戈诺阿疟疾流行村居民的无症状疟疾感染负担和持续时间进行了测量。比较了4岁至成年人群中恶性疟原虫、间日疟原虫和疟疾疟原虫的感染情况。每隔3天进行一次频繁采样，最长可达61天，可对个别感染事件进行评估。恶性疟原虫检测的统计评估显示，在长达27天的时间内，该物种的同步复制具有周期性。在所有年龄组中，恶性疟原虫发作的持续时间都比间日疟原虫和疟疾疟原虫长。在每个物种的数据中也注意到持续时间随年龄减少的趋势。这在恶性疟原虫感染中最为突出：4岁儿童的中位病程为48天，而年龄较大的儿童和成人的中位病程为9至15天。这一结果与对抗原性多样化的疟原虫群体缓慢获得免疫一致，表明间日疟原虫和疟疾疟原虫的获得速度比恶性疟原虫快。
The burden and duration of asymptomatic malaria infections were measured in residents of the malaria endemic village of Gonoa, Madang Province, Papua New Guinea. Plasmodium falciparum, P. vivax and P. malariae infections in people aged 4 years to adulthood were compared. Frequent sampling at 3-day intervals for up to 61 days allowed assessment of individual episodes of infection. Statistical assessment of P. falciparum detection revealed a periodicity consistent with synchronous replication of this species over periods up to 27 days. The duration of P. falciparum episodes was longer across all age groups than that of P. vivax and P. malariae. A trend for decreasing duration with age was also noted in data from each species. This was most prominent in P. falciparum infections: median duration in 4-year-olds was > 48 days compared with a median between 9 and 15 days in older children and adults. The results are consistent with the slow acquisition of immunity to antigenically diverse Plasmodium populations and suggest a faster rate of acquisition to P. vivax and P. malariae than to P. falciparum.