Behaviour and interactions of proteins and peptides with and within membranes; from simple models to cellular membranes: general discussion.
Behaviour and interactions of proteins and peptides with and within membranes; from simple models to cellular membranes: general discussion.
复制标题
蛋白质和肽在膜上和膜内的行为和相互作用；
DOI：
10.1039/d1fd90067f
复制
发表时间：
2021
影响因子：
3.4
通讯作者：
Hoogenboom,Bart
中科院分区：
文献类型：
--
作者：
Aguilar,Mibel;AlNahas,Kareem;Barrera,Francisco;Bassereau,Patricia;Bastos,Margarida;Beales,Paul;Bechinger,Burkhard;Bonev,Boyan;Brand,Izabella;Chattopadhyay,Amitabha;DeGrado,William;Fuchs,Patrick;GarciaSaez,AnaJ;Hoogenboom,Bart
Shobhna Kapoor回答说：是的，膜上脂质的电荷确实影响了它与细胞骨架的相互作用。在我们的工作中（DOI：10.1039/d 0 fd 00051 e），一些分枝杆菌脂质在生理条件下没有净电荷，并且这些脂质不影响膜粘附能（意味着膜-细胞骨架相互作用没有变化）。然而，这些并不妨碍肌动蛋白的形态重新分布。最有可能的是，细菌脂质与其下方的宿主细胞膜/肌动蛋白网络之间的静电相互作用在选择性招募宿主蛋白质和脂质中发挥作用，影响膜-细胞骨架相互作用。
Shobhna Kapoor responded: Yes, the charge of the lipids on the membrane does in uence its interaction with the cytoskeleton. In our work (DOI: 10.1039/d0fd00051e), some mycobacterial lipids had no net charge at physiological conditions and these lipids did not affect the membrane adhesion energy (implying no changes to the membrane–cytoskeletal interactions). However, these did in uence the actin morphology re-distribution. Most likely, the electrostatic interactions between bacterial lipids and the host cell membrane/actin network underneath it play a role in the selective recruitment of host proteins and lipids, impacting the membrane–cytoskeletal interactions.