Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4
Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4
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DOI：
10.1016/s0092-8674(00)81436-1
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发表时间：
1998-05-29
期刊：
影响因子：
64.5
通讯作者：
Anderson, DJ
中科院分区：
文献类型：
--
作者：
Wang, HU;Chen, ZF;Anderson, DJ
脊椎动物的循环系统由动脉和静脉组成。这些血管之间的功能和病理差异被认为反映了生理差异，如氧合和血压。在这里，我们发现ephrin-B2，一个Eph家族跨膜配体，从血管生成开始标记动脉内皮细胞而不是静脉内皮细胞。相反，ephrin-B2的受体Eph-B4标记静脉而不是动脉。ephrin-B2基因敲除小鼠头部和卵黄囊毛细血管网络中的动脉和静脉血管生成以及心肌小梁均出现缺陷。这些结果提供了证据，表明动脉和静脉之间的差异部分是由遗传决定的，并表明这两种血管之间的相互信号传导对毛细血管床的形态发生至关重要。
The vertebrate circulatory system is composed of arteries and veins. The functional and pathological differences between these vessels have been assumed to reflect physiological differences such as oxygenation and blood pressure. Here we show that ephrin-B2, an Eph family transmembrane ligand, marks arterial but not venous endothelial cells from the onset of angiogenesis. Conversely, Eph-B4 a receptor for ephrin-B2, marks veins but not arteries. ephrin-B2 knockout mice display defects in angiogenesis by both arteries and veins in the capillary networks of the head and yolk sac as well as in myocardial trabeculation. These results provide evidence that differences between arteries and veins are in part genetically determined and suggest that reciprocal signaling between these two types of vessels is crucial for morphogenesis of the capillary beds.