ADRB3 Polymorphism Associated with BMI Gain in Japanese Men
ADRB3 Polymorphism Associated with BMI Gain in Japanese Men
复制标题
ADRB3 多态性与日本男性 BMI 增加相关
DOI：
--
复制
发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Y. Kuroda
中科院分区：
文献类型：
--
作者：
S. Takeuchi;T. Katoh;Takenori Yamauchi;Y. Kuroda
objective.本研究的目的是评估健康日本人β 3-肾上腺素能受体基因（ADRB 3：rs4994）Trp64 Arg多态性与BMI、血清学和人体测量学数据之间的相关性。方法.在日本一家大型综合生产机构招募的健康日本人（N = 1355;年龄：37.25 ± 9.43; BMI：22.86 ± 3.46）有资格进行分析。在全面健康检查期间测量人体测量数据和血清学数据，并使用自我报告问卷评估20岁时的生活习惯（当前运动、吸烟状况、饮酒和工作方式）和体重。采用PCR-RFLP方法对ADRB 3基因多态性进行基因分型。结果在1355名受试者中，Trp/Trp、Trp/Arg和Arg/Arg变异的基因型频率分别为920（67.9%）、394（29.1%）和41（3.05%）。在多变量分析中，男性的多元线性回归模型对年龄、饮酒习惯、吸烟习惯、运动习惯、工作状态和血清学测量进行了统计学调整，结果显示，从20岁起每年BMI增加与年龄、LDL或ADRB 3多态性之间总体上存在弱显著性。结论. LDL水平、年龄和ADRB3多态性（Arg/Arg基因型）与日本男性的年BMI增加有统计学相关性。
Objective. The aim of this study was to evaluate the association between the Trp64Arg polymorphism in the beta3-adrenergic receptor gene (ADRB3: rs4994) and BMI and serological and anthropometric data in healthy Japanese. Methods. Healthy Japanese recruited in a large-scale integrated manufacturing facility in Japan (N = 1355; age: 37.25 ± 9.43; BMI: 22.86 ± 3.46) were eligible for analysis. The anthropometric data and serological data were measured during a comprehensive health check, and a self-reporting questionnaire was used to assess lifestyle habits (current exercise, smoking status, alcohol intake, and working style) and weight at age 20. Genotyping for the ADRB3 polymorphism was performed by PCR-RFLP method. Results. Among 1355 participants, the genotype frequencies of the Trp/Trp, Trp/Arg, and Arg/Arg variants were 920 (67.9%), 394 (29.1%), and 41 (3.05%), respectively. In the multivariate analysis, a multiple linear regression model in men for the adjustment of age, drinking habits, smoking habits, exercise habits, working status and serological measurements statistically showed an overall weak significance between annual BMI gain from age 20 and age, LDL or ADRB3 polymorphism. Conclusions. The level of LDL, age, and ADRB3 polymorphism (Arg/Arg genotype) were statistically associated with annual BMI gain in Japanese men.
影响因子：
158.5
作者：
WALSTON, J;SILVER, K;SHULDINER, AR
通讯作者：
SHULDINER, AR
阴毛早熟儿童和雄激素过多症青春期女孩的体重指数与 β(3)-肾上腺素能受体变异体 (W64R) 之间没有关联。
影响因子：
6.7
作者：
Witchel,SF;Fagerli,J;Siegel,J;Smith,R;Mitwally,MF;Lewy,V;Arslanian,S;Lee,PA
通讯作者：
Lee,PA