Synthesis, Characterization, and Cytotoxicity of Iron Oxide Nanoparticles
Synthesis, Characterization, and Cytotoxicity of Iron Oxide Nanoparticles
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DOI：
10.1155/2013/710432
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发表时间：
2013-01-01
影响因子：
--
通讯作者：
Ahsanul, K.
中科院分区：
文献类型：
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作者：
Kanagesan, S.;Hashim, M.;Ahsanul, K.
为了研究纳米粒子对人乳腺癌细胞的作用，以Fe（NO3）3中心点9 H（2）O为原料，采用简单的低温燃烧法合成了氧化铁（α-Fe 2 O3）纳米粒子。X射线衍射研究证实，所得粉末是纯的α-Fe 2 O3。透射电子显微镜研究揭示了初级颗粒的球形形状，并且氧化铁纳米颗粒的尺寸在19 nm的范围内。磁滞回线表明，样品暴露出铁磁行为与相对较低的矫顽力。还在人乳腺癌细胞上评估了α-Fe 2 O3纳米颗粒的细胞毒性，以解决目前对纳米颗粒暴露的细胞反应的知识不足。
In order to study the response of human breast cancer cells' exposure to nanoparticle, iron oxide (alpha-Fe2O3) nanoparticles were synthesized by a simple low temperature combustion method using Fe(NO3)(3)center dot 9H(2)O as raw material. X-ray diffraction studies confirmed that the resultant powders are pure alpha-Fe2O3. Transmission electron microscopy study revealed the spherical shape of the primary particles, and the size of the iron oxide nanoparticles is in the range of 19 nm. The magnetic hysteresis loops demonstrated that the sample exposed ferromagnetic behaviors with a relatively low coercivity. The cytotoxicity of alpha-Fe2O3 nanoparticle was also evaluated on human breast cancer cells to address the current deficient knowledge of cellular response to nanoparticle exposure.