Dynamic model of the process of protein synthesis in eukaryotic cells.
Dynamic model of the process of protein synthesis in eukaryotic cells.
复制标题
真核细胞蛋白质合成过程的动态模型。
DOI：
10.1007/s11538-006-9128-2
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发表时间：
2007
影响因子：
3.5
通讯作者：
Morris,DavidR
中科院分区：
文献类型：
--
作者：
Skjondal-Bar,Nadav;Morris,DavidR
蛋白质合成是所有细胞中基因表达的最后一步。为了理解这一过程的监管，拥有一个包含监管步骤的准确模型非常重要。本文提出的模型由一组微分方程组成，这些微分方程描述了起始过程的动力学及其控制，以及肽延伸，从可用于肽生成的氨基酸开始。一种模拟延伸过程的新方法可以有效预测蛋白质的产生、能量和氨基酸的消耗，以及 mRNA 上的核糖体装载率和核糖体间距。
Protein synthesis is the final step of gene expression in all cells. In order to understand the regulation of this process, it is important to have an accurate model that incorporates the regulatory steps. The model presented in this paper is composed of set of differential equations which describe the dynamics of the initiation process and its control, as well as peptide elongation, starting with the amino acids available for peptide creation. A novel approach for modeling the elongation process permits useful prediction of protein production and consumption of energy and amino acids, as well as ribosome loading rate and ribosome spacing on the mRNA.