Surgical placement of customized abdominal vagus nerve stimulating and gastrointestinal serosal surface recording electrodes.
Surgical placement of customized abdominal vagus nerve stimulating and gastrointestinal serosal surface recording electrodes.
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DOI：
10.1093/jscr/rjab463
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发表时间：
2021-10
影响因子：
0.5
通讯作者：
Ahmed BH
中科院分区：
文献类型：
--
作者：
Horn CC;Wong L;Shepard BS;Gourash WF;McLaughlin BL;Fisher LE;Ahmed BH
控制迷走神经到器官信号传导的生物电子医学方法具有治疗心脏、呼吸、胃肠道（GI）和代谢疾病（例如肥胖症）的潜力。与颈部迷走神经刺激（VNS）不同，腹部VNS可以提供胃肠道的特定治疗控制，而不会对胸部器官产生脱靶效应;然而，腹部VNS电极放置的手术方法尚未确立。此外，用于闭环控制的最佳设备配置和GI记录电极的额外放置在很大程度上是未知的。我们设计了VNS袖带和GI平面Sercantine电极，并在两具尸体的腹腔镜手术中测试了这些器械的放置。我们确定腹侧迷走神经和胃窦上的电极定位是可行的，但其他部位，如十二指肠和近端胃，更困难。目前的研究可以指导潜在的放置和设计的VNS袖带和GI电极的闭环GI治疗设备的发展。
Bioelectronic medical approaches to control vagus nerve-to-organ signaling have the potential to treat cardiac, respiratory, gastrointestinal (GI) and metabolic diseases, such as obesity. Unlike cervical vagus nerve stimulation (VNS), abdominal VNS could provide specific therapeutic control of the GI tract without off-target effects on thoracic organs; however, surgical approaches for abdominal VNS electrode placement are not well established. Moreover, optimal device configurations and additional placement of GI recording electrodes for closed-loop control are largely unknown. We designed VNS cuff and GI planar serosal electrodes and tested placement of these devices in laparoscopic surgery in two cadavers. We determined that electrode positioning on the ventral abdominal vagus nerve and gastric antrum was feasible but other sites, such as the duodenum and proximal stomach, were more difficult. The current investigation can guide potential placement and design of VNS cuff and GI electrodes for development of closed-loop GI therapeutic devices.