Recent Advances in Catalytic Asymmetric Syntheses of Functionalized Heterocycles via Halogenation/Chalcogenation of Carbon‐Carbon Unsaturated Bonds
Recent Advances in Catalytic Asymmetric Syntheses of Functionalized Heterocycles via Halogenation/Chalcogenation of Carbon‐Carbon Unsaturated Bonds
复制标题
碳-碳不饱和键卤化/硫属化催化不对称合成功能化杂环的最新进展
DOI：
10.1002/adsc.202200611
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发表时间：
2022-10
影响因子：
5.4
通讯作者：
Jun Deng
中科院分区：
文献类型：
--
作者：
Shengshu Liu;Bing‐Qian Zhang;Wen‐Ying Xiao;Yin‐Long Li;Jun Deng
含卤素（氟、氯、溴、碘）或硫族元素（硫、硒）的杂环被广泛认为是许多天然产物和生物活性靶标的关键结构单元。碳-碳不饱和键的催化不对称卤化/硫代反应-离子交换反应是获得多种手性杂环骨架的有效方法。在过去的几年中，用各种卤素和硫族亲电试剂进行的卤代/硫代/硒代官能化的催化对映选择性版本经历了不断的发展。本文综述了手性有机催化剂或金属催化剂在制备功能化杂环化合物方面的研究进展。
Halogen (fluorine, chlorine, bromine, iodine) or chalcogen (sulfur, selenium)‐containing heterocycles are widely recognized as key building blocks in many natural products and bioactive targets. Catalytic asymmetric halogenation/chalcogenation of carbon‐carbon unsaturated bondsviaonium ion transformations are efficient methods to obtain diverse chiral heterocyclic backbones. In the past few years, catalytic enantioselective versions of halo/thio/seleno‐functionalizations with various halogen and chalcogen electrophiles have experienced constant development. This review highlights those advances in preparing functionalized heterocycles promoted by chiral organocatalysts or metal‐based catalysts.