A mouse model of non-Shiga toxin-associated haemolytic uraemic syndrome.
A mouse model of non-Shiga toxin-associated haemolytic uraemic syndrome.
复制标题
非志贺毒素相关溶血尿毒症综合征的小鼠模型。
DOI：
10.1093/ndt/gfm758
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Remuzzi,Giuseppe
中科院分区：
文献类型：
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作者：
Caprioli,Jessica;Remuzzi,Giuseppe
Impaired control of the complement system activation due to mutations in complement factor H (CFH) has been described in two apparently unrelated human diseases, membranoproliferative glomerulonephitis type II (MPGN2) and non-Shiga toxin-associated haemolytic uraemic syndrome (non-Stx-HUS). Mouse models of these diseases have been developed by Pickering et al., by knocking-out Cfh gene (MPGN2) and by subsequently transferring a mutated Cfh gene in the Cfh−/− background (non-Stx-HUS). The data obtained from the two models provided precious information to clarify the mechanisms that cause the disparate phenotypes underlying CFH genetic defect.
