The interactive language of the hypothalamus for the gonadotropin releasing hormone (GNRH) system.
The interactive language of the hypothalamus for the gonadotropin releasing hormone (GNRH) system.
复制标题
下丘脑促性腺激素释放激素 (GNRH) 系统的交互语言。
DOI：
10.1046/j.1365-2826.1997.00619.x
复制
发表时间：
1997
影响因子：
3.2
通讯作者：
Kalra,PS
中科院分区：
文献类型：
--
作者：
Kalra,SP;Horvath,T;Naftolin,F;Xu,B;Pu,S;Kalra,PS
The enormous diversity in neurochemical signals employed within the network of afferents to GnRH neurons is well‐documented. An examination of novel and accumulating knowledge on the operation of these messengers indicates the presence of an interactive language governing GnRH secretion. The basic operational structures identified to date to affirm this interactive form of communication summarized in this review are the following: (i) the demonstration of interconnections within various components of the afferent network; (ii) coexistence and possible co‐release of excitatory and inhibitory neurotransmitters/ neuromodulators; (iii) co‐action of various messengers at synaptic targets, and (4) modulation by gonadal steroids of the synthesis and release of signals and their receptors, and induction of synaptic plasticity for the timely relay of signals for GnRH secretion. Unraveling the molecular sequelae that promote this interactive communication to elicit periodic GnRH secretion is now a new challenge.
