Emotional enhancement of memory via amygdala-driven facilitation of rhinal interactions
Emotional enhancement of memory via amygdala-driven facilitation of rhinal interactions
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DOI：
10.1038/nn1771
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发表时间：
2006-10-01
影响因子：
25
通讯作者：
Pare, Denis
中科院分区：
文献类型：
--
作者：
Paz, Rony;Pelletier, Joe Guillaume;Pare, Denis
情绪通常促进记忆，这是一种由基底外侧杏仁核（BLA）介导的效应。为了研究潜在的机制，我们记录了食欲痕迹条件反射任务中BLA、嗅周和嗅内神经元的变化。我们把重点放在鼻皮质上，因为它们构成了海马体（记忆巩固的中介）和新皮层（陈述性记忆的存储地点）之间的界面。我们发现，在意外奖励之后，BLA活动增加了从嗅周神经元到嗅内神经元的冲动传递，并且随着条件刺激和奖励之间的关联被学习，这种效应减弱。在学习的这个后期阶段，当动物期待奖励时，BLA效应就会发生。通过加强对感觉线索的处理，bla介导的鼻部相互作用的促进可以解释杏仁核如何促进情绪条件下的记忆形成。
Emotions generally facilitate memory, an effect mediated by the basolateral amygdala (BLA). To study the underlying mechanisms, we recorded BLA, perirhinal and entorhinal neurons during an appetitive trace-conditioning task. We focused on the rhinal cortices because they constitute the interface between the hippocampus, a mediator of memory consolidation, and the neocortex, the storage site of declarative memories. We found that, after unexpected rewards, BLA activity increased impulse transmission from perirhinal to entorhinal neurons and that this effect decayed as the association between conditioned stimuli and rewards was learned. At this late phase of learning, the BLA effect occurred when the animals were anticipating the reward. By enhancing the processing of sensory cues, the BLA-mediated facilitation of rhinal interactions may explain how the amygdala promotes memory formation in emotional conditions.