Preparation of Dental Resins Resistant to Enzymatic and Hydrolytic Degradation in Oral Environments.
Preparation of Dental Resins Resistant to Enzymatic and Hydrolytic Degradation in Oral Environments.
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DOI：
10.1021/acs.biomac.5b01069
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发表时间：
2015-10-12
影响因子：
6.2
通讯作者：
Sun J
中科院分区：
文献类型：
--
作者：
Gonzalez-Bonet A;Kaufman G;Yang Y;Wong C;Jackson A;Huyang G;Bowen R;Sun J
传统的牙科复合修复材料的平均使用寿命短，以及复合修复剂和密封剂附近继发性龋齿的发生率增加，这使得开发新的、更持久的组合物成为必要。需要新型单体及其聚合物、增强填料和粘合剂组分。本研究的目标是开发用于牙科护理、密封剂和其他牙科服务的树脂系统，其性能和耐久性上级目前使用的双酚A二甲基丙烯酸缩水甘油酯/三甘醇二甲基丙烯酸酯（Bis-GMA/TEGDMA）和双酚-二甲基丙烯酸酯产品。醚基单体和它们的聚合物，不容易酶或水解降解的制备和表征。它们在水解和酶促挑战下没有显示出降解，而酯键的水解在这些挑战下在16天内削弱了当代树脂。基于醚的材料的成功是有希望的，使持久的系统，在口腔环境中受到长期的生化和水解的挑战。
The short average service life of traditional dental composite restorative materials and increasing occurrence of secondary caries adjacent to composite restorations and sealants are necessitating the development of new, longer lasting compositions. Novel monomers and their polymers, reinforcing fillers, and adhesive components are needed. The goal of this research is to develop resin systems for use in restorations, sealants, and other dental services that are superior in properties and endurance to currently used bisphenol A glycidyl dimethacrylate/triethylene glycol dimethacrylate (Bis-GMA/TEGDMA) and urethane–dimethacrylate products. Ether-based monomers and their polymers that were not susceptible to enzymatic or hydrolytic degradation were prepared and characterized. They showed no degradation under hydrolytic and enzymatic challenges, whereas the hydrolysis of ester links weakened contemporary resins within 16 days under these challenges. The success of the ether-based materials is promising in making durable systems that are subjected to long-term biochemical and hydrolytic challenges in oral environments.