Evidence for an association of serum microanalytes and myofascial pain syndrome.
Evidence for an association of serum microanalytes and myofascial pain syndrome.
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DOI：
10.1186/s12891-023-06744-9
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发表时间：
2023-08-01
影响因子：
2.3
通讯作者：
中科院分区：
文献类型：
--
作者：
肌筋膜疼痛综合征(MPS)是一种常见的疼痛障碍。诊断标准包括通常不可靠或不被普遍接受的体检结果。精确的生物标记可能会提高诊断和治疗效果。这项研究的目的是评估微量分析是否与MPS患者的特征性临床结果显著相关。这项描述性的前瞻性研究包括38名参与者(25名女性)，他们的上斜方肌肌筋膜疼痛超过3个月。评估是在一所大学的实验室进行的。主要观察指标为Beighton指数、肩关节活动度、力量不对称性和微量分析：脱氢表雄酮、犬尿氨酸、血管内皮生长因子、白介素类(IL-1b、IL-2、IL-4、IL-5、IL-7、IL-8、IL-13)、生长因子(IGF-1、IGF2、G-CSF、GM-CSF)、MCP-1、MIP-1b、BDNF、多巴胺、去甲肾上腺素、NPY和乙酰胆碱。Spearman的分析结果被用来生成标准相关矩阵和热图矩阵。参与者的平均年龄为32岁(20-61岁)。8例(21%)有广泛性疼痛(广泛性疼痛指数 ≥ 7)。13例(34%)有1-3年的MPS，14(37%)有3-10年的MPS，11(29%)有10年的 >； 。IL-1b、2、4、5、7、8、GM-CSF与IL-2、4、5、7之间、DHEA与BDNF之间、BDNF与犬尿氨酸、神经肽Y、乙酰胆碱之间有较强的相关性。热图分析显示，Beighton指数与IL-5、7、GM-CSF、DHEA之间存在较强的相关性。与精选微量分析物相关的肩部和颈椎运动和强度的不对称。细胞因子水平与选定的临床评估显著相关。这间接暗示了理解MPS可能的生物学相关性。某些细胞因子簇之间的相互关系，以及DHEA、BDNF犬尿氨酸、NPY和乙酰胆碱可能共同作用于MPS。这些发现应该进一步调查，以确认这些微量分析与MPS患者的特定临床结果之间的联系。
Myofascial Pain Syndrome (MPS) is a common pain disorder. Diagnostic criteria include physical findings which are often unreliable or not universally accepted. A precise biosignature may improve diagnosis and treatment effectiveness. The purpose of this study was to assess whether microanalytic assays significantly correlate with characteristic clinical findings in people with MPS. This descriptive, prospective study included 38 participants (25 women) with greater than 3 months of myofascial pain in the upper trapezius. Assessments were performed at a university laboratory. The main outcome measures were the Beighton Index, shoulder range of motion, strength asymmetries and microanalytes: DHEA, Kynurenine, VEGF, interleukins (IL-1b, IL-2, IL-4, IL-5, IL-7, IL-8, IL-13), growth factors (IGF-1, IGF2, G-CSF, GM-CSF), MCP-1, MIP-1b, BDNF, Dopamine, Noradrenaline, NPY, and Acetylcholine. Mann–Whitney test and Spearman’s multivariate correlation were applied for all variables. The Spearman’s analysis results were used to generate a standard correlation matrix and heat map matrix. Mean age of participants was 32 years (20–61). Eight (21%) had widespread pain (Widespread Pain Index ≥ 7). Thirteen (34%) had MPS for 1–3 years, 14 (37%) 3–10 years, and 11 (29%) for > 10 years. The following showed strong correlations: IL1b,2,4,5,7,8; GM-CSF and IL 2,4,5,7; between DHEA and BDNF and between BDNF and Kynurenine, NPY and acetylcholine. The heat map analysis demonstrated strong correlations between the Beighton Index and IL 5,7, GM-CSF, DHEA. Asymmetries of shoulder and cervical spine motion and strength associated with select microanalytes. Cytokine levels significantly correlate with selected clinical assessments. This indirectly suggests possible biological relevance for understanding MPS. Correlations among some cytokine clusters; and DHEA, BDNF kynurenine, NPY, and acetylcholine may act together in MPS. These findings should be further investigated for confirmation that link these microanalytes with select clinical findings in people with MPS.
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影响因子：
2
作者：
Bron, Carel;Franssen, Jo;Oostendorp, Rob
通讯作者：
Oostendorp, Rob
影响因子：
3.1
作者：
Fernandez-de-las-Penas, Cesar;Dommerholt, Jan
通讯作者：
Dommerholt, Jan
影响因子：
2.9
作者：
Deitos, Alicia;Dussan-Sarria, Jairo A.;Caumo, Wolnei
通讯作者：
Caumo, Wolnei
DOI：
10.1016/j.arth.2020.02.046
发表时间：
2020-06
期刊：
The Journal of arthroplasty
影响因子：
--
作者：
Malahias MA;Birch GA;Zhong H;Sideris A;Gonzalez Della Valle A;Sculco PK;Kirksey M
通讯作者：
Kirksey M
影响因子：
2
作者：
Cheatham, Scott W.;Kolber, Morey J.;Hanney, William J.
通讯作者：
Hanney, William J.