Multifunctionalized mesoporous silica as an efficient reversed-phase/anion exchange mixed-mode sorbent for solid-phase extraction of four acidic nonsteroidal anti-inflammatory drugs in environmental water samples
Multifunctionalized mesoporous silica as an efficient reversed-phase/anion exchange mixed-mode sorbent for solid-phase extraction of four acidic nonsteroidal anti-inflammatory drugs in environmental water samples
复制标题
多功能介孔二氧化硅作为高效反相/阴离子交换混合模式吸附剂，用于环境水样中四种酸性非甾体抗炎药的固相萃取
DOI：
10.1016/j.chroma.2017.10.051
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发表时间：
2017-12-08
影响因子：
4.1
通讯作者：
Chen, Jiping
中科院分区：
文献类型：
--
作者：
Li, Yun;Huang, Chaonan;Chen, Jiping
A mesoporous silica Santa Barbara.Amorphous-15 (SBA-15) has been first functionalized with 3-[2-(2-aminoethylamino)ethylamino]propyl-trimethoxysilane (a silane with three amines) and then reacted with an excess of phenyl glycidyl ether to generate a mixed-mode anion-exchanger containing both anion-exchange (three amines) and reversed-phase (multiple ether-linked phenyls) functionalities in a single branched ligand. The resulting material has been characterized by scanning electron microscopy, transmission electron microscopy, nitrogen adsorption-desorption measurements, Fourier-transform infrared spectroscopy, and elemental analysis. The results obtained indicated a BET specific surface area (S-BET) of 362.5 m(2) g(-1), a pore volume of 0.70 cm(3) g(-1) with a narrow pore size distribution centered at 6.6 nm, and carbon and nitrogen contents of 28.30% and 2.84%, respectively. The dimensions of these particles (similar to 5 mu m diameter, similar to 60 mu m length), their large surface areas, their high-density functionalities and anion-exchange mixed-mode characteristics make them very attractive for highly effective solid phase extraction (SPE) of acidic nonsteroidal anti-inflammatory drugs (NSAIDs). The important parameters on extraction efficiency including sample pH, breakthrough volume, type and volume of eluent were optimized. A simple and sensitive analytical method based on mixed-mode SPE coupled to high-performance liquid chromatography with ultraviolet detection (HPLC-UV) was developed and successfully applied to the analysis of four NSAIDs (ketoprofen, naproxen, diclofenac, and ibuprofen) in spiked real water samples with satisfactory recoveries (80.6-110.9%) and repeatability (relative standard deviation
