Mechanical, compositional, and microstructural changes caused by human skin maceration
Mechanical, compositional, and microstructural changes caused by human skin maceration
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DOI：
10.1016/j.eml.2020.101017
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发表时间：
2020-11-01
影响因子：
4.7
通讯作者：
German, Guy K.
中科院分区：
文献类型：
--
作者：
Dhandapani, Niranjana;Samuelsson, Kristin;German, Guy K.
我们量化了长期暴露在水中对人类皮肤的机械、成分和结构退化的影响。这种环境暴露与皮炎、浸泡足综合征和战壕足的发病机制有关。单轴拉伸测量显示，当允许在高相对湿度下平衡时，年龄在27到87岁之间的孤立角质层(SC)的水浸泡可以显著地使组织僵硬，并导致塑性和断裂能的降低。随后的吸水研究表明，水浸泡导致的塑料延伸性降低是由于组织的保水能力降低所致。反过来，这种保留量的减少是由血脂和天然保湿因子的耗尽造成的。对SC机械性能的进一步研究进一步揭示了大约70年的清晰轮廓。采用这种基于年龄的分类，我们确定了70岁以上的SC在水中浸泡的降解性影响最大。全层皮肤的组织学检查进一步显示，长时间浸水7天会导致表皮剥离、SC空化和真皮胶原完整性降解。然而，将皮肤浸泡在温度较低的水中会减少这种降解。(C)2020爱思唯尔有限公司。保留所有权利。
We quantify the effects of prolonged exposure to water on the mechanical, compositional and structural degradation of human skin. This environmental exposure is associated with maceration and the pathogenesis of dermatitis, immersion foot syndrome, and trench foot. Uniaxial tensometry reveals that water immersion of isolated stratum corneum (SC) ranging in age across 27 to 87 years can notably stiffen the tissue and cause both reductions in plasticity and rupture energy when allowed to equilibrate to a high relative humidity. Subsequent water sorption studies reveal that water immersion induced decreases in plastic extensibility are caused by a reduction in the tissue's ability to hold water. In turn, this retention decrease is caused by a depletion in both lipids and natural moisturising factors. Further scrutiny of SC mechanical properties further reveals a clear delineation around 70 years. Employing this age-based categorisation, we establish that the degradative impact of water immersion is greatest for SC aged over 70 years. Histological examinations of full-thickness skin further reveal that prolonged water immersion for 7 days causes epidermal delamination, SC cavitation, and degradation in dermal collagen integrity. Immersion of skin in water at colder temperatures however reduces this degradation. (C) 2020 Elsevier Ltd. All rights reserved.