Emerging Benefits: Pathophysiological Functions and Target Drugs of the Sigma-1 Receptor in Neurodegenerative Diseases
Emerging Benefits: Pathophysiological Functions and Target Drugs of the Sigma-1 Receptor in Neurodegenerative Diseases
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新兴优势：Sigma-1 受体在神经退行性疾病中的病理生理功能和靶向药物
DOI：
10.1007/s12035-021-02524-5
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发表时间：
2021-08-12
影响因子：
5.1
通讯作者：
Chen，Qing-jie
中科院分区：
文献类型：
--
作者：
Wu，Ning-hua;Ye，Yu;Chen，Qing-jie
sigma-1受体（Sig-1 R）由SIGMAR 1基因编码，是一种非阿片类跨膜受体，位于垂体相关内质网膜（MAM）。它有助于定位内质网钙通道，调节钙稳态，并作为分子伴侣控制细胞命运和参与信号转导。它通过多种信号通路对神经元起着重要的保护作用，并参与与神经退行性疾病密切相关的认知和运动行为的调节。基于其神经保护作用，Sig-1 R现已成为缓解阿尔茨海默病和其他神经退行性疾病的突破性靶点。本文综述了sigma-1受体在正常或病理状态下的功能以及sigma-1受体靶向药物在神经退行性疾病中的最新研究进展。
The sigma-1 receptor (Sig-1R) is encoded by theSIGMAR1gene and is a nonopioid transmembrane receptor located in the mitochondrial-associated endoplasmic reticulum membrane (MAM). It helps to locate endoplasmic reticulum calcium channels, regulates calcium homeostasis, and acts as a molecular chaperone to control cell fate and participate in signal transduction. It plays an important role in protecting neurons through a variety of signaling pathways and participates in the regulation of cognition and motor behavior closely related to neurodegenerative diseases. Based on its neuroprotective effects, Sig-1R has now become a breakthrough target for alleviating Alzheimer’s disease and other neurodegenerative diseases. This article reviews the most cutting-edge research on the function of Sig-1R under normal or pathologic conditions and target drugs of the sigma-1 receptor in neurodegenerative diseases.