Effects of hypnotics on the sleep EEG of healthy young adults: new data and psychopharmacologic implications
Effects of hypnotics on the sleep EEG of healthy young adults: new data and psychopharmacologic implications
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DOI：
10.1016/s0022-3956(00)00038-8
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发表时间：
2000-11-01
影响因子：
4.8
通讯作者：
Campbell, IG
中科院分区：
文献类型：
--
作者：
Feinberg, I;Maloney, T;Campbell, IG
苯二氮卓类催眠药通过减少德尔塔(0.3-3赫兹)，增加西格玛(12-15赫兹)和β(15-231-12)活动，增加NREM睡眠并改变其脑电。我们测试了非苯二氮卓类催眠药唑吡坦(10 Mg)是否与两种经典的苯二氮卓类药物三唑仑(0.25 mg)和替马西潘(30 Mg)产生相同的睡眠模式和脑电变化。对16名受试者在服药和服用安慰剂期间的3个晚上的睡眠脑电进行了周期幅度分析。与经典的苯二氮卓类药物相比，唑吡坦的作用方向相同，但通常幅度较小。这些差异更有可能是不同剂量的结果，而不是不同的药理作用。周期振幅分析表明，三角洲活动性降低的主要原因是波幅的降低。相反，Sigma和β活性的增加是由波的入射增加引起的。Delta抑制随给药次数增加而增加，但Sigma和β刺激不增加。虽然这些发现与临床选择催眠药的相关性不大，但它们可能对涉及催眠耐受和戒断精神错乱的大脑机制有重要影响。(C)2001爱思唯尔科学有限公司。保留所有权利。
Benzodiazepine hypnotics increase NREM sleep and alter its EEG by reducing delta (0.3-3 Hz) and increasing sigma (12-15 Hz) and beta (15-23 1-12) activity. We tested whether the nonbenzodiazepine hypnotic, zolpidem (10 mg), produced the same pattern of sleep and EEG changes as two "classical" benzodiazepines, triazolam (0.25 mg) and temazepam (30 mg). Sleep EEG of 16 subjects was analyzed with period amplitude analysis for 3 nights during drug administration or placebo. The effects of zolpidem were in the same direction but generally of smaller magnitude than those of the classical benzodiazepines. These differences are more likely the result of non-equivalent dosages than different pharmacologic actions. Period amplitude analysis showed that the decreased delta activity resulted mainly from a decrease in wave amplitude. In contrast, the increased sigma and beta activity were produced by increased wave incidence. Delta suppression increased with repeated drug administration but sigma and beta stimulation did not. While these findings have little relevance for the clinical choice of hypnotics they may hold important implications for the brain mechanisms involved in hypnotic tolerance and withdrawal delirium. (C) 2001 Elsevier Science Ltd. All rights reserved.