KL-6 is Not Ineffective Biomarker of Indium Lung
KL-6 is Not Ineffective Biomarker of Indium Lung
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KL-6 并非无效的铟肺生物标志物
DOI：
10.1007/s00420-013-0873-x
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Hirata M
中科院分区：
文献类型：
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作者：
Nakano M;Omae K;Tanaka A;Hirata M
据报道，血清Krebs von den Lungen-6 (KL-6)（Kohno et al. 1989）是铟诱发肺部疾病最敏感的生物标志物（Chonan et al. 2007; Hamaguchi et al. 2008; Nakano et al. 2009）。Liu等人（2012）在之前的报告中指出，氧化铟锡（ITO）加工工人血清中KL-6没有升高，并建议KL-6可能不是评估ITO工人健康状况的适当指标。然而，他们的论文中报道的KL-6值与我们的文章（Chonan et al. 2007; Hamaguchi et al. 2008; Nakano et al. 2009）有很大不同。我们推测造成差异的原因可能是血清KL-6测量的差异，并使用“人类克雷伯斯-永登- Lundgen-6酶联免疫吸附测定试剂盒”（Cusabio Biotech Co., Ltd., Cat）比较了他们的方法。否。CSB-E12700h，中国)(KL-6C)（Cusabio Biotech Co. 2013）采用Picolumi KL-6试剂盒（EIDIA Co. Ltd, Japan）（KL-6J）（EIDIA Co. 2013）对66名日本铟暴露工人（平均年龄46岁，SD 13.3，血清中铟范围：\ 0.1-69.5 μg/L）进行检测。KL-6C和KL-6J的测定在一个全国性的临床实验室（特殊参考实验室，日本东京）进行。低于检出限（3.9 U/ml）的KL-6C被归为任意值3.9 U/ml。KL-6C和KL-6J的几何均数（几何标准差）分别为5.00 U/ml（1.63）和345.4 U/ml（1.86）。图1是KL-6J和KL-6C的散点图，如图所示
It has been reported that serum Krebs von den Lungen-6 (KL-6)(Kohno et al. 1989) is the most sensitive biomarker of indium-induced lung disease (Chonan et al. 2007; Hamaguchi et al. 2008; Nakano et al. 2009). In a previous report, Liu et al.(2012) noted that serum KL-6 was not elevated in indium tin oxide (ITO) processing workers and suggested that KL-6 may not be an appropriate indicator for evaluating the health of ITO workers. However, the KL-6 values reported in their paper are extremely different from those in our articles (Chonan et al. 2007; Hamaguchi et al. 2008; Nakano et al. 2009). We presumed that the cause of the difference may be a discrepancy in the measurement of serum KL-6 and compared their method using the ‘‘Human Krebs yon den Lundgen-6 ELISA Kit’’(Cusabio Biotech Co., Ltd., Cat. no. CSB-E12700h, China)(KL-6C)(Cusabio Biotech Co. 2013) with our method using the Picolumi KL-6 kit (EIDIA Co., Ltd., Japan)(KL-6J)(Eidia Co. 2013) in 66 Japanese indium-exposed workers (mean age 46 year, SD 13.3, range of indium in serum:\0.1–69.5 μg/L). The measurement of KL-6C and KL-6J was performed at a nationwide clinical laboratory (Special Reference Laboratory, Tokyo, Japan). KL-6C below the detection limit (3.9 U/ml) was ascribed to an arbitrary value of 3.9 U/ml. The geometric means (geometric standard deviation) of KL-6C and KL-6J were 5.00 U/ml (1.63) and 345.4 U/ml (1.86), respectively. Figure 1 is a scatter chart of KL-6J and KL-6C and showed