AGING AND NEUROTOXINS AS CAUSATIVE FACTORS IN IDIOPATHIC PARKINSONS-DISEASE - A CRITICAL ANALYSIS OF THE NEUROCHEMICAL EVIDENCE
AGING AND NEUROTOXINS AS CAUSATIVE FACTORS IN IDIOPATHIC PARKINSONS-DISEASE - A CRITICAL ANALYSIS OF THE NEUROCHEMICAL EVIDENCE
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DOI：
10.1016/0278-5846(89)90121-8
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发表时间：
1989-01-01
影响因子：
5.6
通讯作者：
HORNYKIEWICZ, O
中科院分区：
文献类型：
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作者：
HORNYKIEWICZ, O
1. 特发性帕金森病（PD）与其他帕金森病的区别在于纹状体多巴胺（DA）的特定区域间（尾状-壳核）和分区域（背侧-尾侧）模式的损失。使用纹状体DA丢失的特征模式作为神经化学标准，对特发性PD的“衰老/神经毒素”假说进行了批判性评估。尽管脑DA神经元和MPTP（作为DA特异性神经毒素的一个例子）的衰老都再现了特发性PD中发现的分区域纹状体DA丢失的某些方面，但这两种机制都无法模仿特发性PD典型的DA丢失的尾状核-壳核差异（壳核比尾状核受影响更大）。从讨论的观察中得出结论，在特发性PD中起作用的病理因素或因素必须涉及一种优先损害投射到壳核的黑质DA神经元的机制。
1. Idiopathic Parkinson's disease (PD) is set apart from other Parkinsonian conditions by a specific interregional (caudate-putamen) as well as a subregional (rostralcaudal) pattern of striatal dopamine (DA) loss.2. Using the characteristic patterns of striatal DA loss as neurochemical criteria, a critical evaluation of the “ageing/neurotoxin” hypothesis of idiopathic PD is presented.3. Although both ageing of the brain DA neurones and MPTP (as an example of a DA-specific neurotoxin) reproduce some aspects of the subregional striatal DA loss found in idiopathic PD, neither of these two mechanisms mimicks the large caudate-putamen difference in DA loss (with the putamen much more affected than the caudate nucleus) which is typical of idiopathic PD.4. From the discussed observations the conclusion is drawn that the pathoetiological factor, or factors, operative in idiopathic PD must involve a mechanism preferentially damaging the nigral DA neurones which project to the putamen.