1-Ethyl-3-methylimidazolium acetate as a highly efficient organocatalyst for cyanosilylation of carbonyl compounds with trimethylsilyl cyanide.
1-Ethyl-3-methylimidazolium acetate as a highly efficient organocatalyst for cyanosilylation of carbonyl compounds with trimethylsilyl cyanide.
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1-乙基-3-甲基咪唑鎓乙酸酯作为高效有机催化剂，用于羰基化合物与三甲基氰硅烷的氰基甲硅烷基化
DOI：
10.1038/srep42699
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发表时间：
2017-02-15
影响因子：
4.6
通讯作者：
Ren Q
中科院分区：
文献类型：
--
作者：
Ullah B;Chen J;Zhang Z;Xing H;Yang Q;Bao Z;Ren Q
介绍了1-乙基-3-甲基咪唑醋酸酯作为一种强大的有机催化剂，用于羰基化合物与三甲基硅氰（TMSCN）的无溶剂氰硅化反应。在温和的反应条件下，催化剂的负载可以降低到0.1-0.0001 mol %，在有机催化转化领域，TOF值从10,843 h−1到10,602,410 h−1相当高。该方法不仅能耐受大量羰基化合物，而且对离子液体催化反应的机理也有一定的了解。
1-Ethyl-3-methylimidazolium acetate is introduced as a robust organocatalyst for solvent-free cyanosilylation of carbonyl compounds with trimethylsilyl cyanide (TMSCN). The catalyst loading can be reduced to as low as 0.1–0.0001 mol % under mild reaction conditions, giving considerably high TOF values from 10,843 h−1 to 10,602,410 h−1 in the field of organocatalyzed transformations. The present protocol not only tolerates with extensive carbonyl compounds but also provides somewhat insight into the mechanism of ionic liquids (ILs)-catalyzed reactions.