Respiratory Diseases in Cyclophosphamide-Treated Mice II. Decreased Virulence of PR8 Influenza Virus
Respiratory Diseases in Cyclophosphamide-Treated Mice II. Decreased Virulence of PR8 Influenza Virus
复制标题
环磷酰胺治疗小鼠的呼吸道疾病 II。
DOI：
10.1128/iai.5.6.957-960.1972
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发表时间：
1972
影响因子：
3.1
通讯作者：
R. Kirschstein
中科院分区：
文献类型：
--
作者：
S. H. Singer;P. Noguchi;R. Kirschstein
鼻内感染流感病毒PR8株的小鼠用环磷酰胺（一种有效的免疫抑制剂）治疗。在感染的第一周，未经修饰的流感感染的死亡率平均为65%，而在那些也用环磷酰胺治疗的动物中，死亡率平均为22.5%。在第一周后，感染的环磷酰胺处理动物的死亡率上升到仅感染的动物的第一周期间所观察到的死亡率。尽管环磷酰胺治疗和感染的动物具有更高的病毒滴度（持续时间更长）、循环抗体降低和干扰素应答降低，但仍发现第一周死亡率降低。这种延迟死亡似乎与感染环磷酰胺处理动物肺中细胞浸润减少的发现有关。
Mice infected intranasally with the PR8 strain of influenza virus were treated with cyclophosphamide, a potent immunologic suppressor. During the first week of infection, mortality in the unmodified influenza infection averaged 65%, whereas in those animals also treated with cyclophosphamide it averaged 22.5%. After the first week, the mortality rate in the infected cyclophosphamide-treated animals rose to that seen during the first week in the animals only infected. This decreased mortality in the first week was found despite the fact that the cyclophosphamide-treated and infected animals had higher virus titers which persisted longer, decreased circulating antibody, and a decreased interferon response. This delayed mortality appeared to be related to the finding of decreased cellular infiltration in the lungs of infected cyclophosphamide-treated animals.