Longitudinal changes in abdominal fat distribution with menopause
Longitudinal changes in abdominal fat distribution with menopause
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DOI：
10.1016/j.metabol.2008.09.030
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发表时间：
2009-03-01
影响因子：
9.8
通讯作者：
Kanaley, Jill A.
中科院分区：
文献类型：
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作者：
Franklin, Ruth M.;Ploutz-Snyder, Lori;Kanaley, Jill A.
据报道，绝经后腹部脂肪增加，但绝经对腹部脂肪分布（内脏与皮下）的影响仍不清楚。这项研究的目的是确定腹部脂肪含量（体积）或分布是否随绝经而改变。磁共振成像被用来量化总腹部，皮下和内脏脂肪在8名健康妇女，无论是在绝经前的状态和8年后的绝经后状态。还测量了体力活动（PA）和血脂。体重和腰围不随绝经而变化（绝经前vs绝经后：体重，63.2 ± 3.1 vs 63.9 ± 2.5 kg;腰围，92.1 ± 4.6 vs 93.4 ± 3.7 cm）;然而，腹部脂肪总量、皮下脂肪和内脏脂肪都显著增加，（P < .05）随绝经而增加（绝经前vs绝经后：总，27154 +/- 4269 vs 34717 +/- 3272 cm（3）;皮下，19981 +/- 3203 vs 24918 +/- 12521 cm（3）;内脏，7173 ± 1611 vs 9798 ± 1644 cm（3））。虽然绝对肥胖随着绝经而改变，但绝经后相对脂肪分布没有显著差异（绝经前与绝经后：皮下，73% +/- 3% vs 71% +/- 3%;内脏，26% +/- 3% vs 28% +/- 3%）。瘦体重，脂肪量，PA，沿着总胆固醇和甘油三酯水平，并没有随着绝经而改变。绝经后高密度脂蛋白和低密度脂蛋白均升高（P <0.05），总胆固醇/高密度脂蛋白比值降低（P <0.05）。通过磁共振成像纵向测量，尽管PA、体重或腰围没有变化，但总腹部脂肪含量随着绝经而增加;然而，绝经并不影响这些女性的相对腹部大鼠分布，（C）2009 Elsevier Inc. All rights reserved.
Increases in abdominal fat have been reported with menopause, but the impact of menopause on abdominal fat distribution (visceral vs subcutaneous) is still unclear. The objective of the Study was to determine if abdominal fat content (volume) or distribution is altered with menopause. Magnetic resonance imaging was used to quantify total abdominal, subcutaneous, and visceral fat in 8 healthy women, both in the premenopausal state and 8 years later in the postmenopausal state. Physical activity (PA) and blood lipids were also measured. Body weight and waist circumference did not change with menopause (pre- vs postmenopause: body weight, 63.2 +/- 3.1 vs 63.9 +/- 2.5 kg; waist circumference, 92.1 +/- 4.6 vs 93.4 +/- 3.7 cm); however, total abdominal fat, subcutaneous fat, and visceral fat all significantly (P < .05) increased with menopause (pre- vs postmenopause: total, 27 154 +/- 4269 vs 34 717 +/- 3272 cm(3); subcutaneous, 19 981 +/- 3203 vs 24 918 +/- 12521 cm(3); visceral, 7173 +/- 1611 vs 9798 +/- 1644 cm(3)). Although absolute adiposity changed with menopause, relative fat distribution was not significantly different after menopause (pre- vs postmenopause: subcutaneous, 73% +/- 3% vs 71% +/- 3%; visceral, 26% +/- 3% vs 28% +/- 3%). Lean mass, fat mass, and PA, along with total cholesterol and triglyceride levels, did not change with menopause. High-density lipoprotein and low-density lipoprotein both increased (P < .05), and the ratio of total cholesterol to high-density lipoprotein decreased (P < .05) with menopause. As measured longitudinally with magnetic resonance imaging, total abdominal fat content increased with menopause despite no change in PA, body weight, or waist circumference; however, menopause did not affect the relative abdominal rat distribution in these women, (C) 2009 Elsevier Inc. All rights reserved.