First Stereoselective Synthesis of Penicillenol A1 via Novel O- to C-Acyl Rearrangement of O-Acyltetramic Acid
First Stereoselective Synthesis of Penicillenol A1 via Novel O- to C-Acyl Rearrangement of O-Acyltetramic Acid
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DOI：
10.1055/s-0030-1259045
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发表时间：
2010-12-01
期刊：
影响因子：
2
通讯作者：
Yoda, Hidemi
中科院分区：
文献类型：
--
作者：
Sengoku, Tetsuya;Wierzejska, Jolanta;Yoda, Hidemi
以L-苏氨酸为起始原料，经9步反应首次立体选择性合成青霉烯醇A（1）。青霉烯醇A（1）的3-酰基特特拉姆酸核心是通过成功的O-到C-酰基重排而构建的。
The first stereoselective synthesis of penicillenol A(1) has been accomplished in nine steps from L-threonine. The 3-acyltetramic acid core of penicillenol A(1) was constructed by successful O- to C-acyl rearrangement.