Physiologic root resorption in primary teeth: molecular and histological events.
Physiologic root resorption in primary teeth: molecular and histological events.
复制标题
DOI：
10.2334/josnusd.49.1
复制
发表时间：
2007-03-01
影响因子：
1.9
通讯作者：
Harokopakis-Hajishengallis, Evlambia
中科院分区：
文献类型：
--
作者：
Harokopakis-Hajishengallis, Evlambia
牙根吸收是乳牙的一种生理现象。目前还不清楚，破牙细胞，吸收牙齿硬组织的细胞，是否不同于破骨细胞，吸收骨的细胞。牙根吸收似乎是由下面恒牙的星状网和牙囊通过分泌刺激分子，即细胞因子和转录因子来启动和调节的。以类似于骨重塑的方式调节主根吸收过程，涉及相同的受体配体系统，称为RANK/RANKL（核因子-κ B/ RANK配体的受体激活剂）。没有恒牙的乳牙最终也会脱落，但我们目前对潜在机制的了解很少。文献也是含糊不清的吸收的牙髓和牙周膜的乳牙发生。了解生理性牙根吸收过程中的机制，可以使我们在恒牙不存在的情况下延迟甚至抑制乳牙的脱落，因此需要保留乳牙。
Root resorption is a physiologic event for the primary teeth. It is still unclear whether odontoclasts, the cells which resorb the dental hard tissue, are different from the osteoclasts, the cells that resorb bone. Root resorption seems to be initiated and regulated by the stellate reticulum and the dental follicle of the underlying permanent tooth via the secretion of stimulatory molecules, i.e. cytokines and transcription factors. The primary root resorption process is regulated in a manner similar to bone remodeling, involving the same receptor ligand system known as RANK/RANKL (receptor activator of nuclear factor-kappa B/ RANK Ligand). Primary teeth without a permanent successor eventually exfoliate as well, but our current understanding on the underlying mechanism is slim. The literature is also vague on how resorption of the pulp and periodontal ligament of the primary teeth occurs. Knowledge on the mechanisms involved in the physiologic root resorption process may enable us to delay or even inhibit exfoliation of primary teeth in those cases that the permanent successor teeth are not present and thus preservation of the primary teeth is desirable.