Gastrin-histamine as a normal sequence in gastric acid stimulation in the rabbit.
Gastrin-histamine as a normal sequence in gastric acid stimulation in the rabbit.
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胃泌素-组胺作为兔子胃酸刺激的正常序列。
DOI：
10.3109/03009737909179150
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发表时间：
1979
影响因子：
3.4
通讯作者：
K. J. Öbrink
中科院分区：
文献类型：
--
作者：
Elisabet Bergqvist;K. J. Öbrink
在离体胃腺的悬浮液中，促分泌素对泌酸细胞的作用只能通过直接刺激来检测。间接刺激如胃泌素诱导一种类型的细胞释放组胺，然后组胺作用于泌酸细胞，由于释放的物质的非常高的稀释度，将是检测不到的。因此，分离的腺体制备提供了一种方法，通过该方法可以将顺序刺激中的两个步骤分开。没有证据表明胃泌素直接作用于泌酸细胞，但它确实以剂量-效应关系释放组胺，这将在完整的胃中产生足以有效刺激酸分泌的组胺浓度。因此，在家兔中，组胺似乎是胃泌素刺激的正常生理介质。
In a suspension of isolated gastric glands the effect of secretagogues on the oxyntic cells can only be detected by direct stimulation. An indirect stimulus like gastrin inducing one type of cell to liberate histamine which then acts on the oxyntic cells will not be detectable because of the very high dilution of the liberated substance. Thus the isolated gland preparation presents a means by which two steps in a sequential stimulation can be separated. There is no evidence that gastrin acts directly on the oxyntic cells but it does liberate histamine in a dose-effect relationship, which would in an intact stomach give histamine concentrations sufficient to effectively stimulate the acid secretion. Thus in the rabbit histamine seems to be a normal physiological mediator for gastrin stimulation.