Holter monitoring of small breed dogs with advanced myxomatous mitral valve disease with and without a history of syncope.
Holter monitoring of small breed dogs with advanced myxomatous mitral valve disease with and without a history of syncope.
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DOI：
10.1111/jvim.12290
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发表时间：
2014-03
影响因子：
2.6
通讯作者：
Olsen LH
中科院分区：
文献类型：
--
作者：
Rasmussen CE;Falk T;Domanjko Petrič A;Schaldemose M;Zois NE;Moesgaard SG;Ablad B;Nilsen HY;Ljungvall I;Höglund K;Häggström J;Pedersen HD;Bland JM;Olsen LH
晕厥是一种短暂的意识丧失，偶尔发生在患有晚期粘液瘤性二尖瓣疾病 (MMVD) 的狗身上。 (1) 研究患有晚期 MMVD 的狗在晕厥发作期间心电图的变化，以及 (2) 比较有和没有晕厥病史的晚期 MMVD 狗之间心律失常的发生和心率变异性 (HRV) 的变化。 43 只患有晚期 MMVD 的私人养犬（<15 公斤）：21 只有晕厥史，22 只没有晕厥史。对招募的狗进行前瞻性研究，进行评估，包括病史、体检、超声心动图、心律失常以及对 24 小时动态心电图记录进行的 HRV 分析。在动态心电图监测期间，4 只狗观察到晕厥发作：3 只狗有窦性心律，1 只狗有窦性停搏，随后出现逃逸心律。有晕厥病史的犬中代表窦性心律失常的心律失常变量显着低于没有晕厥病史的犬 (P = .008)。 26 个 HRV 变量中的 8 个在有或没有晕厥病史的狗之间存在显着差异。与没有晕厥史的狗相比，患有晚期MMVD和晕厥史的狗心律失常的发生率并不较高，但窦性心律失常较少，并且HRV变量发生变化，表现为总体HRV降低、副交感神经减弱和心率的交感神经调节增加。
Syncope is a transient loss of consciousness occasionally occurring in dogs with advanced myxomatous mitral valve disease (MMVD). (1) To study ECG changes during syncopal episodes in dogs with advanced MMVD and (2) to compare the occurrence of arrhythmias and changes in heart rate variability (HRV) between dogs with advanced MMVD with and without a history of syncope. Forty‐three privately owned dogs (<15 kg) with advanced MMVD: 21 with and 22 without a history of syncope. Prospective study with dogs recruited for an evaluation including history, physical examination, echocardiography, and arrhythmia and HRV analysis performed on 24‐hour Holter recordings. A syncopal episode was observed during Holter monitoring in 4 dogs: 3 dogs had sinus rhythm and 1 dog had sinus arrest followed by escape rhythm. An arrhythmia variable representing sinus arrhythmia was significantly lower in dogs with a history of syncope than in those without (P = .008). Eight of 26 HRV variables were significantly different between dogs with and without a history of syncope. Compared with dogs without a history of syncope, dogs with advanced MMVD and a history of syncope did not have a higher occurrence of arrhythmias, but had less sinus arrhythmia, and had changes in HRV variables representing decreased overall HRV, decreased parasympathetic, and increased sympathetic modulation of heart rate.