Intermediate filament proteins participate in signal transduction
Intermediate filament proteins participate in signal transduction
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DOI：
10.1016/j.tcb.2005.09.009
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发表时间：
2005-11-01
影响因子：
19
通讯作者：
Goldman, RD
中科院分区：
文献类型：
--
作者：
Helfand, BT;Chou, YH;Goldman, RD
如何在长轴突的远端和神经元的细胞体之间及时地传递化学信号是一个有趣而又悬而未决的问题。最近，Perlson et al.有证据表明，新合成的波形蛋白(一种中间丝(IF)蛋白)的切割产物与轴突损伤部位的丝裂原激活蛋白(MAP)激酶相互作用。这些IF片段似乎是这些激酶沿着微管轨迹运输到细胞体所必需的。截短的波形蛋白在信号传播中起重要作用，因为它提供了一个支架，将激活的MAP激酶(如ERK1和ERK2)以及Importinβ和细胞质dynein聚集在一起。作者认为，这种一体化的运输复合体具有非凡的能力，可以向细胞体移动并进入细胞核，在那里激活并影响基因表达，从而使神经元能够对损伤产生及时的反应。
How timely transport of chemical signals between the distal end of long axonal processes and the cell bodies of neurons occurs is an interesting and unresolved issue. Recently, Perlson et al. presented evidence that cleavage products of newly synthesized vimentin, an intermediate filament (IF) protein, interact with mitogen-activated protein (MAP) kinases at sites of axon injury. These IF fragments appear to be required for the transport of these kinases to the cell body along microtubule tracks. The truncated vimentin is instrumental in signal propagation as it provides a scaffold that brings together activated MAP kinases (such as Erk 1 and Erk2), as well as importin beta and cytoplasmic dynein. The authors propose that this all-in-one transport complex has the extraordinary ability to travel towards the cell body and enter the nucleus where the kinases activate and influence gene expression so that a neuron can generate a timely response to injury.