Differential involvement of the dorsal anterior cingulate and prelimbic-infralimbic areas of the rodent prefrontal cortex in spatial working memory.
Differential involvement of the dorsal anterior cingulate and prelimbic-infralimbic areas of the rodent prefrontal cortex in spatial working memory.
复制标题
啮齿动物前额叶皮层的背侧前扣带回和前边缘-下边缘区域在空间工作记忆中的差异参与。
DOI：
10.1037//0735-7044.112.2.293
复制
发表时间：
1998
影响因子：
1.9
通讯作者：
Kesner,RP
中科院分区：
文献类型：
--
作者：
Ragozzino,ME;Adams,S;Kesner,RP
[更正通知：这篇文章的错误报告在《行为神经科学》第112卷第4期（见记录2008-09590-001）。]图1（第295页）和图4（第299页）打印错误。更正后的图表页和相应的标题在勘误表中提供。本研究使用go/no-go程序研究了喹啉酸损伤对前扣带背和边缘前皮层-边缘下皮层空间工作记忆和空间辨别的影响。所有的测试都在一个12臂放射状迷宫中进行。在一项工作记忆任务中，老鼠被允许进入12个手臂，以获得谷物奖励。三个或四个手臂在一个回合中第二次出现，这不会产生奖励。在空间辨别任务中，大鼠连续进入2个不同的手臂。一只手臂上总是放着奖赏，而另一只手臂上从不放奖赏。边缘前-边缘下损伤损害了空间工作记忆，但只产生短暂的空间辨别缺陷。背侧前扣带损伤在两项任务中均未引起缺陷。这些发现表明，边缘前-边缘下皮层在空间工作记忆中起重要作用，而不是前扣带皮层。（PsycINFO数据库记录(c) 2016 APA，版权所有）
[Correction Notice: An erratum for this article was reported in Vol 112 (4) of Behavioral Neuroscience (see record 2008-09590-001). Figure 1 (page 295) and Figure 4 (page 299) were printed incorrectly. The corrected figure pages and corresponding captions are provided in the erratum.] The present study examined the effects of quinolinic acid lesions of the dorsal anterior cingulate and prelimbic–infralimbic cortices on spatial working memory and spatial discrimination using go/no-go procedures. All testing occurred in a 12-arm radial maze. In a working memory task, rats were allowed to enter 12 arms for a cereal reward. Three or 4 arms were presented for a 2nd time in a session, which did not result in a reward. In a spatial discrimination task, rats had successive access to 2 different arms. One arm always contained a reward, and the other never contained a reward. Prelimbic–infralimbic lesions impaired spatial working memory but only produced a transient spatial discrimination deficit. Dorsal anterior cingulate lesions did not induce a deficit in either task. These findings suggest that the prelimbic–infralimbic cortices, but not the anterior cingulate cortex, are important in spatial working memory.(PsycINFO Database Record (c) 2016 APA, all rights reserved)