Relationships between gray matter, body mass index, and waist circumference in healthy adults
Relationships between gray matter, body mass index, and waist circumference in healthy adults
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DOI：
10.1002/hbm.22021
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发表时间：
2013-07-01
影响因子：
4.8
通讯作者：
Narr, Katherine L.
中科院分区：
文献类型：
--
作者：
Kurth, Florian;Levitt, Jennifer G.;Narr, Katherine L.
肥胖和超重通常由身体质量指数(BMI)来定义，BMI与新陈代谢和心血管疾病有关，也可能与痴呆症和脑体积变化有关。然而，与BMI相比，体脂分布和腹型肥胖(以腰围衡量)与心血管和代谢风险的相关性更强。虽然先前的研究已经揭示了灰质组织体积和BMI之间的负相关，但与腰围的关系在很大程度上仍未被探索。因此，我们研究了体重指数和腰围对115名健康受试者局部灰质体积的影响，筛选对象排除了可能影响中枢神经系统的生理或精神障碍。结果显示，体重指数与腰围呈显著负相关，其中灰质对下丘脑的影响最大，并进一步包围了前额叶、前颞叶和下顶叶皮质，以及小脑。然而，与BMI相比，腰围的关联更广泛和明显。后续分析显示，这些关系在不同性别之间存在显著差异。虽然男性的BMI和腰围的相关性相似，但女性的腰围显示出更广泛的相关性。我们的观察表明，腰围是一个比BMI更敏感的指标，特别是在女性身上，可以潜在地确定肥胖和超重对大脑的不利影响以及相关的健康风险。Hum Brain Mapp，2013年。(C)2011年威利期刊公司。
Obesity and overweight are often defined by the body mass index (BMI), which associates with metabolic and cardiovascular disease, and possibly with dementia as well as variations in brain volume. However, body fat distribution and abdominal obesity (as measured by waist circumference) is more strongly correlated with cardiovascular and metabolic risk than is BMI. While prior studies have revealed negative associations between gray matter tissue volumes and BMI, the relationship with respect to waist circumference remains largely unexplored. We therefore investigated the effects of both BMI and waist circumference on local gray matter volumes in a group of 115 healthy subjects screened to exclude physical or mental disorders that might affect the central nervous system. Results revealed significant negative correlations for both BMI and waist circumference where regional gray matter effects were largest within the hypothalamus and further encompassed prefrontal, anterior temporal and inferior parietal cortices, and the cerebellum. However, associations were more widespread and pronounced for waist circumference than BMI. Follow-up analyses showed that these relationships differed significantly across gender. While associations were similar for both BMI and waist circumference for males, females showed more extensive correlations for waist circumference. Our observations suggest that waist circumference is a more sensitive indicator than BMI, particularly in females, for potentially determining the adverse effects of obesity and overweight on the brain and associated risks to health. Hum Brain Mapp, 2013. (c) 2011 Wiley Periodicals, Inc.