MOLECULAR-CLONING AND CHARACTERIZATION OF THE RAT NMDA RECEPTOR
MOLECULAR-CLONING AND CHARACTERIZATION OF THE RAT NMDA RECEPTOR
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DOI：
10.1038/354031a0
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发表时间：
1991-11-07
期刊：
影响因子：
64.8
通讯作者：
NAKANISHI, S
中科院分区：
文献类型：
--
作者：
MORIYOSHI, K;MASU, M;NAKANISHI, S
编码大鼠NMDA受体的互补DNA已被克隆和鉴定。由该基因编码的单一蛋白质形成受体-通道复合体，该复合体具有NMDA受体特有的电生理和药理特性。该蛋白与AMPA/海人藻酸受体有显著的序列相似性，并含有四个假定的跨膜片段，位于一个较大的胞外区之后。NMDA受体信使RNA在整个脑区的神经细胞中都有表达，特别是在海马区、大脑皮层和小脑。
A complementary DNA encoding the rat NMDA receptor has been cloned and characterized. The single protein encoded by the cDNA forms a receptor-channel complex that has electrophysiological and pharmacological properties characteristic of the NMDA receptor. This protein has a significant sequence similarity to the AMPA/kainate receptors and contains four putative transmembrane segments following a large extracellular domain. The NMDA receptor messenger RNA is expressed in neuronal cells throughout the brain regions, particularly in the hippocampus, cerebral cortex and cerebellum.