Sex differences in resting state brain function of cigarette smokers and links to nicotine dependence.
Sex differences in resting state brain function of cigarette smokers and links to nicotine dependence.
复制标题
DOI：
10.1037/pha0000033
复制
发表时间：
2015-08
影响因子：
2.3
通讯作者：
Wilson SJ
中科院分区：
文献类型：
--
作者：
Beltz AM;Berenbaum SA;Wilson SJ
性别——生物和社会个体差异的标志——对吸毒尤其是吸烟很重要，而吸烟是美国可预防死亡的主要原因。吸烟的男性多于女性，但女性戒烟的可能性低于男性。静息状态的大脑功能，或在没有目标导向任务的情况下发生的内在大脑活动，对于理解吸烟非常重要，因为它已被证明可以区分吸烟者和非吸烟者。但是，目前尚不清楚性别是否以及如何影响静息状态大脑功能与吸烟行为之间的联系。在这项研究中，我们证明性别确实与吸烟者的静息状态连通性有关，并且性别调节了静息状态连通性和自我报告的尼古丁依赖之间的联系。使用功能性磁共振成像和 50 名成年每日吸烟者（23 名女性）的行为数据，我们发现在默认模式网络中女性比男性具有更强的连接性，并且奖励网络内连接性的增加与女性尼古丁耐受性增加有关，但与男性尼古丁耐受性降低有关。研究结果强调了静息状态连通性所反映的与性别相关的个体差异对于理解药物使用问题的病因和治疗的重要性。
Sex – a marker of biological and social individual differences – matters for drug use, particularly for cigarette smoking, which is the leading cause of preventable death in the United States. More men than women smoke, but women are less likely than men to quit. Resting state brain function, or intrinsic brain activity that occurs in the absence of a goal-directed task, is important for understanding cigarette smoking, as it has been shown to differentiate between smokers and non-smokers. But, it is unclear whether and how sex influences the link between resting state brain function and smoking behavior. In this study, we demonstrate that sex is indeed associated with resting state connectivity in cigarette smokers, and that sex moderates the link between resting state connectivity and self-reported nicotine dependence. Using functional magnetic resonance imaging and behavioral data from 50 adult daily smokers (23 women), we found that women had greater connectivity than men within the default mode network, and that increased connectivity within the reward network was related to increased nicotine tolerance in women but to decreased nicotine tolerance in men. Findings highlight the importance of sex-related individual differences reflected in resting state connectivity for understanding the etiology and treatment of substance use problems.