Cell-mediated delivery of synthetic nano- and microparticles
Cell-mediated delivery of synthetic nano- and microparticles
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DOI：
10.1016/j.jconrel.2017.01.048
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发表时间：
2017-08-10
影响因子：
10.8
通讯作者：
Klok, Harm-Anton
中科院分区：
文献类型：
--
作者：
Ayer, Maxime;Klok, Harm-Anton
基于合成纳米和微粒的药物载体的细胞介导递送是增强对药物分布的控制和改善靶向的非常有前途的策略。本文将介绍一个概述的工作，这已经做了探索细胞表面修饰策略的合成纳米和微粒的细胞搭便车。本文的第一部分将介绍和讨论不同类型的细胞已被探索为细胞介导的药物输送。本综述的第二部分将讨论各种化学策略，已制定的共轭或固定的纳米和微粒的表面上的这些细胞。(C)2017爱思唯尔B.V.保留所有权利。
Cell mediated delivery of synthetic nano- and microparticle based drug carriers is a very promising strategy to enhance control over the distribution of drugs and improve targeting. This article will present an overview of work, which has been done to explore cell surface modification strategies for the cellular hitchhiking of synthetic nano-and microparticles. The first part of this article will present and discuss the different types of cells that have been explored for cell mediated drug delivery. The second part of this review will discuss the various chemical strategies that have been elaborated for the conjugation or immobilization of nano-and microparticles on the surface of these cells. (C) 2017 Elsevier B.V. All rights reserved.