SPINAL-CORD ENERGY-METABOLISM IN NORMAL AND POST-LAMINECTOMY CATS
SPINAL-CORD ENERGY-METABOLISM IN NORMAL AND POST-LAMINECTOMY CATS
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DOI：
10.3171/jns.1980.52.3.0387
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发表时间：
1980-01-01
影响因子：
4.1
通讯作者：
WATERS, TR
中科院分区：
文献类型：
--
作者：
ANDERSON, DK;MEANS, ED;WATERS, TR
本研究确定了猫腰椎上段 (L-2) 和下段 (L-5) 中 ATP、ADP、AMP、磷酸肌酸 (P-肌酸)、葡萄糖、乳酸和丙酮酸的正常浓度，以及先前报道的椎板切除术引起的脊髓血流 (SCBF) 减少是否导致脊髓能量代谢紊乱。 L-5 期的 ATP、P-肌酸、丙酮酸和葡萄糖浓度显着高于 L-2 期，这可能是由于 L-5 期灰质数量多于 L-2 期的结果。 ADP 和 AMP 水平的显着增加是椎板切除术后 15 分钟观察到的唯一代谢物变化。 ADP 和 AMP 的增加可能是由于椎板切除术引起的 ATP 利用刺激。其他代谢物缺乏变化意味着有效的能量稳态。虽然椎板切除术可以减少 SCBF，但这种减少的程度显然不足以对脊髓能量代谢产生不利影响。椎板切除部位下方或附近的组织是可行的并且基本正常。
This study determined normal concentrations of ATP, ADP, AMP, phosphocreatine (P-creatine), glucose, lactate and pyruvate in upper (L-2) and lower (L-5) feline lumbar spinal cord, and whether previously reported laminectomy-induced reduction in spinal cord blood flow (SCBF) resulted in disturbance of spinal cord energy metabolism. Concentrations of ATP, P-creatine, pyruvate and glucose were significantly higher at L-5 than at L-2, probably as the result of larger amounts of gray matter at L-5 than L-2. Significant increases in ADP and AMP levels were the only metabolite changes noted 15 min following laminectomy. The increase in ADP and AMP may be due to a laminectomy-induced stimulation of ATP utilization. Lack of change in other metabolites implies an efficient energy homeostasis. Although laminectomy can reduce SCBF, the degree of this reduction is apparently insufficient to adversely affect spinal cord energy metabolism. Tissue from beneath or near the laminectomy site is viable and essentially normal.