Epigenetic programing of cancer stemness by transcription factors-non-coding RNAs interactions
Epigenetic programing of cancer stemness by transcription factors-non-coding RNAs interactions
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DOI：
10.1016/j.semcancer.2023.04.005
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发表时间：
2023-04-13
影响因子：
14.5
通讯作者：
Ahmad, Aamir
中科院分区：
文献类型：
--
作者：
Alsayed, Reem Khaled M. E.;Sheikhan, Khalid Sultan A. M.;Ahmad, Aamir
癌症的“干性”是癌症存在的基础。它定义了癌细胞无限延续和分化的能力。生长肿瘤内的癌症干细胞群除了在癌症转移中发挥重要作用外，还有助于逃避化疗和放疗的抑制作用。NF-κ B和STAT-3是代表性的转录因子（TF），其长期以来与癌症干性相关，因此呈现为癌症治疗的有吸引力的靶点。近年来，对非编码RNA（ncRNA）的兴趣日益增加，为TF影响癌症干细胞特性的机制提供了进一步的见解。有证据表明，转录因子通过ncRNA，如microRNA（miRNA）、长链非编码RNA（lncRNA）以及环状RNA（circRNA）直接调节，反之亦然。此外，TF-ncRNA调节通常是间接的，涉及ncRNA靶基因或单个ncRNA对其他ncRNA种类的海绵作用。信息正在迅速发展，这篇综述提供了一个全面的审查TF-ncRNA相互作用与癌症的干性和治疗的影响。这些知识将有助于揭示控制癌症干性的多层次严格监管，在此过程中为治疗提供新的机会和目标。
Cancer 'stemness' is fundamental to cancer existence. It defines the ability of cancer cells to indefinitely perpetuate as well as differentiate. Cancer stem cell populations within a growing tumor also help evade the inhibitory effects of chemo- as well as radiation-therapies, in addition to playing an important role in cancer metastases. NF-KB and STAT-3 are representative transcription factors (TFs) that have long been associated with cancer stemness, thus presenting as attractive targets for cancer therapy. The growing interest in non-coding RNAs (ncRNAs) in the recent years has provided further insight into the mechanisms by which TFs influence cancer stem cell characteristics. There is evidence for a direct regulation of TFs by ncRNAs, such as, microRNAs (miRNAs), long non-coding RNAs (lncRNAs) as well as circular RNAs (circRNAs), and vice versa. Additionally, the TF-ncRNAs regulations are often indirect, involving ncRNA-target genes or the sponging of other ncRNA species by individual ncRNAs. The information is rapidly evolving and this review provides a comprehensive review of TF-ncRNAs interactions with implications on cancer stemness and in response to therapies. Such knowledge will help uncover the many levels of tight regulations that control cancer stemness, providing novel opportunities and targets for therapy in the process.