SUB-RETINAL NEOVASCULARIZATION - NATURAL-HISTORY OF AN EXPERIMENTAL-MODEL
SUB-RETINAL NEOVASCULARIZATION - NATURAL-HISTORY OF AN EXPERIMENTAL-MODEL
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DOI：
10.1001/archopht.1982.01030040784015
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发表时间：
1982-01-01
影响因子：
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通讯作者：
RYAN, SJ
中科院分区：
文献类型：
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作者：
RYAN, SJ
视网膜下反应的特征在于其由视网膜下新生血管形成决定的许多表现。许多进展在临床[在人类]和组织病理学的相关性，但视网膜下新生血管的发病机制还没有达到一个明确的理解在基础水平。需要确定发病机制和理解治疗的基本原理，强烈主张开发一个合适的视网膜下新生血管形成的实验模型[恒河猴]。黄斑比鼻侧至神经头或周边区域更易发生视网膜下新生血管。在实验诱导的视网膜下新生血管中发生自发性血管化，强调了该模型系统的临床相关性。为今后的形态学关联和模型系统的后续操作提供了依据。
The disciform response is characterized by its many manifestations determined by subretinal neovascularization. Many advances were made clinically [in humans] and with histopathologic correlation, but a clear understanding of the pathogenesis of subretinal neovascularization was not yet achieved at the basic level. The need to determine the pathogenesis and understand the rationale for therapy argues strongly for the development of a suitable experimental model [rhesus monkey] of subretinal neovascularizaton. The macula is much more predisposed to the development of subretinal neovascularization than is the area nasal to the nerve head or the periphery. Spontaneous hemorrhages in experimentally induced subretinal neovascularization occurred, underscoring the clinical relevance of this model system. The basis for future morphologic correlation and subsequent manipulations of this model system was provided.