Unanswered Questions Regarding Sex and BMP/TGF-β Signaling.
Unanswered Questions Regarding Sex and BMP/TGF-β Signaling.
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DOI：
10.3390/jdb6020014
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发表时间：
2018-06-16
影响因子：
2.7
通讯作者：
Rogers MB
中科院分区：
文献类型：
--
作者：
Shah TA;Rogers MB
BMP 和 TGF-β 信号通路之间的串扰调节从胚胎发生的最早阶段到成年生命的许多复杂的发育过程。在许多情况下，这两种信号传导途径相互作用。例如，TGF-β信号传导通常是促纤维化的，而BMP信号传导是抗纤维化和促钙化的。性别特异性差异存在于包括心血管病理在内的许多疾病中。狭窄瓣膜中纤维化和钙化比例的不同表明男性和女性的 BMP/TGF-β 信号传导可能有所不同。在这篇综述中，我们重点关注当前对性别与 BMP/TGF-β 信号传导之间相互作用的理解，并提出了几个尚未解答的问题。
Crosstalk between the BMP and TGF-β signaling pathways regulates many complex developmental processes from the earliest stages of embryogenesis throughout adult life. In many situations, the two signaling pathways act reciprocally. For example, TGF-β signaling is generally pro-fibrotic, whereas BMP signaling is anti-fibrotic and pro-calcific. Sex-specific differences occur in many diseases including cardiovascular pathologies. Differing ratios of fibrosis and calcification in stenotic valves suggests that BMP/TGF-β signaling may vary in men and women. In this review, we focus on the current understanding of the interplay between sex and BMP/TGF-β signaling and pose several unanswered questions.