Incidence of childhood cancer: experience of a decade in a population-based registry.
Incidence of childhood cancer: experience of a decade in a population-based registry.
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DOI：
10.1093/jnci/70.1.49
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发表时间：
1983
期刊：
影响因子：
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通讯作者：
S. Kramer;A. Meadows;P. Jarrett;A. Evans
中科院分区：
文献类型：
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作者：
S. Kramer;A. Meadows;P. Jarrett;A. Evans
使用来自大特拉华州谷（GDV）儿科肿瘤登记处的数据，生成了1970-79年期间0-14岁儿童的癌症发病率。这个基于人口的登记研究覆盖了31个县，儿科基础人口为200万。在此期间，该区域诊断出约2 300例儿童癌症。所有组织学类型合并的发病率与美国和西欧进行的其他大型调查的发病率相似。然而，GDV中某些组织学特异性比率因种族而异。在GDV中，相对于白人，非白人有更高的比率发生维尔姆斯瘤、软组织肉瘤（横纹肌肉瘤除外）和视网膜母细胞瘤。这些对比得到了非洲人群调查的支持，这些调查显示非洲黑人儿童中这些肿瘤的发病率相对较高。GDV白人在急性白血病、神经母细胞瘤和尤文氏肉瘤的发病率方面超过非白人。非洲黑人儿童患这些肿瘤的几率也很低。中枢神经系统肿瘤的频率是相似的GDV白人和非白人，尽管这些肿瘤在非洲黑人罕见的报告。发病率的变化揭示了具有特定肿瘤易感性的人群亚组，并可能提供遗传和环境对观察到的模式的相对影响的线索。
Incidence rates of cancer among children aged 0-14 for the period 1970-79 have been generated with the use of data from the Greater Delaware Valley (GDV) Pediatric Tumor Registry. This population-based registry covers a 31-county area and has a pediatric base population of 2 million. During the period, approximately 2,300 cases of childhood cancer were diagnosed in the region. Incidence rates for all histologic types combined are similar to rates from other large surveys conducted in the United States and Western Europe. However, certain histology-specific rates in the GDV vary by race. In the GDV nonwhites relative to whites have higher rates of Wilms' tumor, soft tissue sarcomas other than rhabdomyosarcoma, and retinoblastoma. These contrasts are supported by surveys in African populations showing relatively higher rates of these tumors among African black children. GDV whites exceed nonwhites in incidence of acute leukemia, neuroblastoma, and Ewing's sarcoma. African black children also experience low rates of these tumors. The frequency of central nervous system tumors is similar for GDV whites and nonwhites, despite reports of a rarity of these neoplasms in African blacks. Variations in incidence rates reveal population subgroups with particular tumor susceptibilities and may provide clues as to the relative influence of heredity and environment on patterns observed.