Wetting the whistle: neurotropic factor improves salivary function.
Wetting the whistle: neurotropic factor improves salivary function.
复制标题
湿润口哨：神经营养因子可改善唾液功能。
DOI：
10.1172/jci77194
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Kimple,RandallJ
中科院分区：
文献类型：
--
作者：
Swick,Adam;Kimple,RandallJ
Xerostomia, or dry mouth, is a common side effect of head and neck radiotherapy, Sjögren syndrome, diabetes, old age, and numerous medications. In this issue of theJCI, Xiao and colleagues identified glial cell line–derived neurotrophic factor (GDNF) as a potential stimulus for salivary stem cell growth. Due to its ability to promote neuronal growth, differentiation, and survival, GDNF is currently being used in clinical trials as a treatment for Parkinson disease; therefore, the findings of Xiao and colleagues may initiate a potential treatment for the millions of patients who suffer from xerostomia each year.
