miRNA deregulation in multiple myeloma
miRNA deregulation in multiple myeloma
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DOI：
10.3760/cma.j.issn.0366-6999.2011.19.037
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发表时间：
2011-10-05
影响因子：
6.1
通讯作者：
Chng Wee Joo
中科院分区：
文献类型：
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作者：
Bi Chong Lei;Chng Wee Joo
多发性骨髓瘤（MM）是一种无法治愈的浆细胞恶性肿瘤，是第二大常见的血液系统癌症。它的特点是复杂的，经常性的遗传和表观遗传异常。最近的出版物已经将miRNA（一类新的基因调节剂）与癌症（包括MM）联系起来。miRNA是约20个核苷酸的单链非编码RNA，其通过mRNA降解或翻译抑制来抑制基因表达。在MM中已经描述了异常的miRNA表达谱，并且它们在MM发病机制中的功能作用正日益被认识到。本文综述了目前关于miRNAs在MM中的作用的文献，并对未来miRNAs在MM管理中的研究和利用提供了展望。中华医学杂志2011;124（19）：3164-3169
Multiple myeloma (MM) is an incurable plasma cell malignancy and is the second most common hematological cancer. It is characterized by complex, recurrent genetic and epigenetic abnormalities. Recent publications have linked miRNAs, a novel class of gene regulators to cancer including MM. miRNAs are about 20 nucleotide, single strand, non-coding RNAs that repress gene expression by mRNA degradation or translational repression. Aberrant miRNA expression profiles have been described in MM, and their functional roles in MM pathogenesis are being increasingly recognized. This review summarizes the current literature on the role of miRNAs in MM and offers perspectives on future research and utilization of miRNAs in MM management. Chin Med J 2011;124(19):3164-3169