Effect of iron deficiency on developing rat brain.
Effect of iron deficiency on developing rat brain.
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DOI：
10.1007/bf02867982
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发表时间：
2002-07-01
期刊：
影响因子：
--
通讯作者：
Seth, P K
中科院分区：
文献类型：
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作者：
Batra, Jyoti;Seth, P K
缺铁会慢慢地经历几个阶段。早期缺铁会导致铁储量的减少，如缺铁母亲所生的7天大的幼崽肝脏非血红素铁水平降低（44%）。血红蛋白水平和PCV（堆积细胞体积）仅在三周后才显著降低。在妊娠和/或哺乳期缺铁1周、2周、3周和4周时，发现发育中的大鼠大脑中GABA （γ -氨基丁酸）转运酶GDH、GAD和GABA-t（谷氨酸脱氢酶、谷氨酸脱羧酶和GABA-转氨酶）活性和GABA含量下降。而GABA结合在不同年龄组均有显著增加。哺乳期暴露期间的铁缺乏仅在3周后的大多数参数中显示出显著的变化。在补铁饮食康复2周后，这些改变的参数不能达到相应的控制值。长期缺铁导致GABA的改变可能导致神经和行为的改变。
Iron deficiency evolves, slowly through several stages. Early iron deficiency caused a depletion in iron stores as shown by a reduction in the levels of hepatic non heme iron (44%) in the 7 days old pups born to iron deficient mothers. The hemoglobin levels and PCV (packed cell volume) were significantly reduced only after the age of three weeks. The activities of GABA (gamma-amino butyric acid) shunt enzymes viz. GDH, GAD and GABA-T (glutamate dehydrogenase, glutamate decarboxylase and GABA-transaminase, respectively) and GABA content were found to decrease during gestation and/or lactation iron deficiency at 1 week (wk), 2wk, 3wk and 4wk of age in the developing rat brains. However GABA binding showed a significant increase at different age groups. The iron deficiency during lactational exposure showed significant alteration in most of the parameters only at the age of 3 weeks onwards. On rehabilitation with iron supplemented diet for 2 weeks, these altered parameters could not attain corresponding control values. A prolonged iron deficiency causing alterations in GABA may lead to neurological and behavioral alterations.