Accelerated healing of diabetic wounds by NorLeu(3)-angiotensin (1-7).
Accelerated healing of diabetic wounds by NorLeu(3)-angiotensin (1-7).
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DOI：
10.1517/13543784.2011.619976
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发表时间：
2011-11
影响因子：
6.1
通讯作者：
Dizerega G
中科院分区：
文献类型：
--
作者：
Rodgers K;Verco S;Bolton L;Dizerega G
糖尿病是一种众所周知的延迟伤口修复的疾病，导致形成定植的慢性伤口。由此产生的溃疡导致发病风险增加，包括骨髓炎和截肢，并增加卫生保健系统的负担。Regranex是唯一一种被批准用于治疗糖尿病溃疡的活性产品，已被证明可以降低截肢风险，但由于已证实的疗效最低以及最近在使用说明书中添加了警告，因此未被广泛使用。本文综述了NorLeu 3-血管紧张素（1-7）（NorLeu 3-A（1-7））作为治疗糖尿病伤口的活性剂的研究进展。NorLeu 3-A（1-7）是天然存在的肽血管紧张素1-7的类似物。作用机制包括诱导祖细胞增殖和加速血管形成、胶原沉积和再上皮化。迄今为止的研究表明，NorLeu 3-A（1-7）在糖尿病伤口闭合方面非常有效，并且在动物研究中上级Regranex。本产品作为慢性伤口愈合的局部制剂的进一步临床开发和本产品加速愈合的机制的研究是必要的。
Diabetes is a disorder that is well known to delay wound repair resulting in the formation of colonized, chronic wounds. The resultant ulcers contribute to increased risk of morbidity, including osteomyelitis and amputations, and increased burden to the health care system. The only active product approved for the treatment of diabetic ulcers, Regranex, has been shown to reduce amputation risk, but is not widely used due to minimal proven efficacy and recent warnings added to the Instructions for Use. Here, we overview the development of NorLeu3-angiotensin (1-7) (NorLeu3-A(1-7)) as an active agent for the treatment of diabetic wounds. NorLeu3-A(1-7) is an analogue of the naturally occurring peptide, angiotensin 1-7. The mechanisms of action include induction of progenitor proliferation and accelerated vascularization, collagen deposition and re-epithelialization. Research to date has shown that NorLeu3-A(1-7) is highly effective in the closure of diabetic wounds and is superior to Regranex in animal studies. Further clinical development of this product as a topical agent for the healing of chronic wounds and investigation into the mechanisms by which this product accelerates healing are warranted.
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影响因子：
16.2
作者：
Wieman, TJ;Smiell, JM;Su, YC
通讯作者：
Su, YC
影响因子：
2.9
作者：
Rodgers, Kathleen;Abiko, Masami;Dizerega, Gere
通讯作者：
Dizerega, Gere
影响因子：
15.9
作者：
Mrug, M;Stopka, T;Prchal, JT
通讯作者：
Prchal, JT
影响因子：
7.5
作者：
Kurosaka, Maya;Suzuki, Tatsunori;Majima, Masataka
通讯作者：
Majima, Masataka
影响因子：
3
作者：
Rodgers, K;Xiong, SQ;diZerega, GS
通讯作者：
diZerega, GS