Subclinical Zinc Deficiency in Alzheimer's Disease and Parkinson's Disease
Subclinical Zinc Deficiency in Alzheimer's Disease and Parkinson's Disease
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DOI：
10.1177/1533317510382283
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发表时间：
2010-11-01
影响因子：
3.4
通讯作者：
Dick, Robert
中科院分区：
文献类型：
--
作者：
Brewer, George J.;Kanzer, Steve H.;Dick, Robert
为了评估阿尔茨海默病和帕金森病的锌状态，研究了29例阿尔茨海默病患者，30例帕金森病患者和29例年龄和性别匹配的对照。所有患者和对照组年龄均大于50岁，并且在研究前30天开始禁止所有锌和铜补充剂。患者根据标准诊断。测定血锌和尿锌。尿锌测定在一个偶然的标本，标准化稀释参考肌酐含量。结果显示，阿尔茨海默氏症患者和帕金森氏症患者的血锌显著低于对照组。与对照组相比，两个患者组的尿锌排泄量（标准化为尿肌酸酐排泄量）均无显着差异。这些病人可能是由于营养不足而缺锌。
To evaluate zinc status in Alzheimer's disease and Parkinson's disease, 29 patients with Alzheimer's disease, 30 patients with Parkinson's disease, and 29 age- and sex-matched controls were studied. All patients and controls were older than age 50, and all zinc and copper supplements were prohibited beginning 30 days prior to study. Patients were diagnosed by standard criteria. Blood zinc and urine zinc were measured. Urine zinc was measured in a casual specimen, standardized for dilution by reference to creatinine content. Results showed a significantly lower blood zinc in patients with Alzheimer's and patients with Parkinson's than in controls. Urine zinc excretion, normalized to urine creatinine excretion, was not significantly different in either patient group compared to controls. These patients are probably zinc deficient because of nutritional inadequacy.